I3C & Trans-Resveratrol

[UNCfan1]

Hey Dinoiii and others what do u guys think about this combo for PCT? They both are SERM in nature. I know Trans-Resveratrol and I3C are as sexy or as well known about with the likes of Nolva, Clomid, Torem and so on, but they seem to be just as good those.

Thoughts?????

I couldn't get ya at DA so I will give u a shotout here

[dinoiii]

Sorry I didn't catch your thread at DA. Perhaps you could post my retort over there for cross-reference to save me a little time?


The information on resveratrol remains in its infancy, though interesting study evolution has resulted from outrageous claims. It is a phytoestrogen (along the lines of soy) that has been shown to function as an estrogen receptor (ER) agonist, but it remains unclear whether it may also exert antagonist activity. The closest we have to antagonistic activity is petri-dish analyses (test tube) data that has been unfortunately not extrapolated correctly by this industry which shows a select antagonism to the ER-alpha, but not ER-beta. Nonetheless, to suggest this be a suitable replacement for curbing elevated estradiol (E2) levels would be WAY off base. And the outrageous amount you would need to exert ANY effect in humans is not even remotely feasible for most anyway – making it quite prohibitive even if it did possess better and more complete direct antagonist properties.

I3C is completely different in nature. Its primary effects on estrogen are to channel various estrogenic metabolites as well as work as a mild aromatase inhibitor. This has no well-defined direct effect at the level of the ER.

That said, combination of I3C and some other ER-antagonist (NOT trans-resveratrol at this time) would likely be a far superior mode based on what data we do have available.



D_

[GotTest]

Originally Posted by dinoiii

I3C is completely different in nature. Its primary effects on estrogen are to channel various estrogenic metabolites as well as work as a mild aromatase inhibitor. This has no well-defined direct effect at the level of the ER.

I dosed 400mg/day during PCT (per your suggestion ) and thought this might have it's place in everyday supplementation, maybe at 200mg/day.

Any thoughts for everyday dosing outside of PCT.

[UNCfan1]

Originally Posted by dinoiii

Sorry I didn't catch your thread at DA. Perhaps you could post my retort over there for cross-reference to save me a little time?


The information on resveratrol remains in its infancy, though interesting study evolution has resulted from outrageous claims. It is a phytoestrogen (along the lines of soy) that has been shown to function as an estrogen receptor (ER) agonist, but it remains unclear whether it may also exert antagonist activity. The closest we have to antagonistic activity is petri-dish analyses (test tube) data that has been unfortunately not extrapolated correctly by this industry which shows a select antagonism to the ER-alpha, but not ER-beta. Nonetheless, to suggest this be a suitable replacement for curbing elevated estradiol (E2) levels would be WAY off base. And the outrageous amount you would need to exert ANY effect in humans is not even remotely feasible for most anyway – making it quite prohibitive even if it did possess better and more complete direct antagonist properties.

I3C is completely different in nature. Its primary effects on estrogen are to channel various estrogenic metabolites as well as work as a mild aromatase inhibitor. This has no well-defined direct effect at the level of the ER.

That said, combination of I3C and some other ER-antagonist (NOT trans-resveratrol at this time) would likely be a far superior mode based on what data we do have available.



D_

Thanks for the reply D. I know u need to consume alot of Revs to make it work but isn't trans-revs different? What about a product that uses it as a transdermal, would that make it more effect?

I will post ur reply at DA for u.