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SuperBig · 08-28-2008, 10:50 AM

D_,

I was reading the the conversion of test->DHT increases as men age, and that was given as one of the factors for prostate maladies, including higher aromitization due to bodyfat deposits as we age.

I was not aware that DHT conversion increases with age. Wouldn't that mean that men produce more 5AR enzyme as they age?

And what role does progesterone play here? This one site was advocating progesterone creams as treatment for prostate maladies as men age, since this helps balance out increased DHT.

**dinoiii** · 08-28-2008, 07:14 PM

Quote:

Originally Posted by SuperBig

D_,

I was reading the the conversion of test->DHT increases as men age, and that was given as one of the factors for prostate maladies, including higher aromitization due to bodyfat deposits as we age.

I was not aware that DHT conversion increases with age. Wouldn't that mean that men produce more 5AR enzyme as they age?

Even if this were the case, you MUST consider the relative ratios. Think about it this way...testosterone decreases an average of 10% over each decade past approximately age 25. That said, if we would like to continue to force blame on DHT, one should probably consider the fact that 100% of males will suffer prostate maladies if they age enough and shifting the blame to DHT was relative ease as we could target an enzyme and subsequently market a drug for it.

The truth is that estrogen INCREASES as we age (and yes, that is due to fat deposition and subsequent aromatization), but this increases the level of DHT receptor, but also presents an imperative binding offering for estrogen and IGF-1 at the level of the prostate membrane where there is a heavier concentration of DHT receptors by chance, but they'd have little effect without the earlier interaction (i.e. - E and IGF-1).

Quote:

And what role does progesterone play here? This one site was advocating progesterone creams as treatment for prostate maladies as men age, since this helps balance out increased DHT.

Progesterone's role is unclear at best. There has NOT been a clearly-identified association here.

What they could have been purporting is that elevation of progesterone keeps the progesterone:estrogen ratio in check however, which is true.

Most, if not all hormones have so many interactions and it is ratios, rather than levels alone that cause most pathology.

D_

B-natural · 08-29-2008, 07:20 AM

Interesting.... and yay I'll be 25 in a couple more weeks

**g_lee** · 08-29-2008, 08:43 AM

Quote:

Originally Posted by B-natural

Interesting.... and yay I'll be 25 in a couple more weeks

to be 25 again....

SuperBig · 08-29-2008, 01:01 PM

Regarding IGF-1:

What implications does this have if one is using products such as Humanofort or Secretagain, which are secretagogue-type formulas, in relation to the prostate? Could you expound on that further?

**dinoiii** · 08-29-2008, 03:26 PM

Quote:

Originally Posted by SuperBig

Regarding IGF-1:

What implications does this have if one is using products such as Humanofort or Secretagain, which are secretagogue-type formulas, in relation to the prostate? Could you expound on that further?

My thoughts are NOT much. It is my assumption that you use said products before bedtime (b/c I have a crystal ball and would know how you would use these items of course - or perhaps more simple in that I know what I recommended). Fortunately, this pre-bedtime offering is teh time when androgens are their lowest.

D_