07-05-2007, 10:17 AM
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#2
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Status: IFFI Control Tower
Join Date: Jun 2007
Location: Rochester, NY / Baltimore, Md / Others
Posts: 2,184
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Sorry I didn't get right to this. There were a lot of things happening in the last couple of days (AX article completion, Newsletter completion and release), and before I answered I wanted to review the actual contents of Leviathan again.
I anticipated one of the indoles to be in the product based on the cut and paste description you offered. As many of you know though (from my PCT articles), I am bigger fan of I3C rather than the metabolite used in this product...due to bioavailability issues amongst many other things. Based on its placement still, I am guessing it has little role that you will see from the product by rules of proprietary blend amongst other things.
That said, even the few effects rendered significant in combo would not "offset" one another in the purest sense as you describe.
If the AI does its part at inhibiting estrogen formation...its action is too far upstream to concern with hydroxy-metabolites, and this doesn't mean you will be estrogen free. That said, any estrogen still circulating in the system will be shunted down the appropriate metabolic pathway (at least hypothetically) and render more of the 2-OH metabolite effective.
D_
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Dana Houser, MD, MHSA, CISSN
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