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muad33b · 07-21-2007, 11:39 AM

I've been taking 3 of these a day (I know it's more then recommended in your fatty-acid thread; http://forum.anabolicx.com/index.php?showtopic=1317):

Guarana (Paullinia cupana) (seed) -- 800mg

(along with a ton of other things, see my CLA/Sesamin thread) and have been noticing that my chest / upper torso is very itchy... am I OD'ing on it?

**dinoiii** · 07-21-2007, 12:38 PM

Well, similar stimulant effects (insomnia, trembling, anxiety, palpitations/irregular heart beat, and urinary frequency) could exist that are cross-referenced to caffeinated agents, however - we still must keep in mind the concentration of caffeine in guarana is somewhat lower and those that assume guarana = caffeine are in a land of confusion (hmmmm, without Genesis being cued in the background - though many not get this reference).

You know, that Fatty Acid Rountable discussion with Dr.D from AX actually was heavily touted at bb.com in its aftermath and there was a LOT of questions regarding this. To follow was a sequence between myself and another poster based on a guarana question you may find of interest.

The question:
http://forum.bodybuilding.com/showpo...1&postcount=25

My response:
http://forum.bodybuilding.com/showpo...1&postcount=26

Something too to watch for (but more often in teas and such with guarana but are still of unknown concern) is the high tannin content which contributes to astringent activity as I mention in that piece above. It will do one of two things, tighten the bowel -or- loosen it. Tannins happen to be a component of one popular supplement on the market these days and this could account for many of the weight loss effects, if any are to be had.

Overall, it seems as though you are handling it well. You can continue on and if it ends up making you feel bad, then stopping use would obviously make sense. That said, keep in mind that the effects also will have a significant wean-off time frame and the potential for withdrawl symptoms (similar to caffeine).

D_

muad33b · 07-21-2007, 06:50 PM

Thanks for the info; everything has been fine with the dosage, with the exception of the chest itchiness; slight rash... it seems to be helping, so I'll suck it up and stick with it for the next couple of weeks, at which point I'm taking a week off from all supplementation when I go on vacation... I won't be back much before you go on your vacation D_, so have a good time, and enjoy your well deserved rest!

**snakemw** · 07-21-2007, 07:26 PM

Great Read D_ as usual. Very interesting the Tannins bind to protein.

thesinner · 08-05-2007, 05:12 PM

Could someone post a link to one of D's threads that goes into further detail about the synergy with guarana & CLA causing apoptosis? This thread has really sparked my interest, but I'm not a member of many of the forums he posts.

**dinoiii** · 08-05-2007, 09:23 PM

Quote:

Originally Posted by thesinner

Could someone post a link to one of D's threads that goes into further detail about the synergy with guarana & CLA causing apoptosis? This thread has really sparked my interest, but I'm not a member of many of the forums he posts.

I think I can oblige you to some degree:

http://forum.anabolicx.com/index.php?showtopic=1317

While that which you are discussing (apoptosis with the combo) has NOT been shown yet in humans (a little bit more challenging obviously), the rodent literature et al is very enticing.

D_

thesinner · 08-05-2007, 09:44 PM

Quote:

Originally Posted by dinoiii

I think I can oblige you to some degree:

http://forum.anabolicx.com/index.php?showtopic=1317

While that which you are discussing (apoptosis with the combo) has NOT been shown yet in humans (a little bit more challenging obviously), the rodent literature et al is very enticing.

D_

Rodent literature holds a lot of weight to me: I'm quite a rat.