Agmatine inhibits NMDA receptors

[pdelta]

Clinically effective drug treatments for spinal cord injury (SCI) remain unavailable. Agmatine, an NMDA receptor antagonist and inhibitor of nitric oxide synthase (NOS), is an endogenous neuromodulator found in the brain and spinal cord. Evidence is presented that agmatine significantly improves locomotor function and reduces tissue damage following traumatic SCI in rats. The results suggest the importance of future therapeutic strategies encompassing the use of single drugs with multiple targets for the treatment of acute SCI. The therapeutic targets of agmatine (NMDA receptor and NOS) have been shown to be critically linked to the pathophysiological sequelae of CNS injury and this, combined with the non-toxic profile, lends support to agmatine being considered as a potential candidate for future clinical applications.


"Agmatine inhibits NMDA receptors. I'll pass

More harm than good. Lets all take a supplement that makes us feel good in the gym but ignore everything else it does in the body. "

Hey Doc some guy called "nattydisaster" claims that he has researched agmatine and claims it inhibits NMDA receptors. What is your take on this claim?

[dinoiii]

Yes, easy one. That's because the person who suggested having "researched" the compound probably looks at and saw an abstract (and quotes this as "research"), but doesn't understand what the hell that means.

For more information for those curious, please see Agmatine slide show in articles section and mechanism #3.


D_