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Owen70 · 10-10-2007, 10:40 PM

dinoiii just interested as to why you're gonna tell me this sucks

specifically, im interested in its ability to elavate thyroid and decrease SHBG as quoted in a study of albino malayasian mice

Thanks D

**dinoiii** · 10-11-2007, 08:55 AM

Well, there is a bit of estrogenic potential which I already described in voo's post on why that would potentially arise [Eurycoma --> (+) CYP17 --> Pregnenelone --> 17-0H Pregnenelone --> 4AD OR DHEA, the latter of which is upstream enough to cause increases in both T AND E]. Some people are finding out about this the hard way with some hyperprolactinemia (high prolactin levels) and galactorrhea (milky breast secretions) with use, but really there is little I see wrong with its use if careful.

What parts of the increasing thyroxine (T4) would you like me to cover? I mean, you must understand that thyroxine which has been shown to increase IS bound to thyroxine-binding globuline (TBG) to a significant degree (percentage will vary upon textbook), but it is pretty high across the board...and that said, it has earned the dubious notion of being dubbed the "inactive" thyroid hormone. If there is no way to increase peripheral conversion to triidothyronine (T3), the point may wind up moot.

As far as the SHBG thing...it looks promising, though has been inconsistent in real humans.

D_

**RisingAgainst** · 10-11-2007, 09:00 AM

Quote:

Originally Posted by dinoiii

Well, there is a bit of estrogenic potential which I already described in voo's post on why that would potentially arise [Eurycoma --> (+) CYP17 --> Pregnenelone --> 17-0H Pregnenelone --> 4AD OR DHEA, the latter of which is upstream enough to cause increases in both T AND E]. Some people are finding out about this the hard way with some hyperprolactinemia (high prolactin levels) and galactorrhea (milky breast secretions) with use, but really there is little I see wrong with its use if careful.

What parts of the increasing thyroxine (T4) would you like me to cover? I mean, you must understand that thyroxine which has been shown to increase IS bound to thyroxine-binding globuline (TBG) to a significant degree (percentage will vary upon textbook), but it is pretty high across the board...and that said, it has earned the dubious notion of being dubbed the "inactive" thyroid hormone. If there is no way to increase peripheral conversion to triidothyronine (T3), the point may wind up moot.

As far as the SHBG thing...it looks promising, though has been inconsistent in real humans.

D_

back to the longjack... what about the apoptosis in breast cells???

**dinoiii** · 10-12-2007, 08:28 AM

Quote:

Originally Posted by RisingAgainst

back to the longjack... what about the apoptosis in breast cells???

Not regular breast cells...cancer breast cells and these are in-vitro cell lines rather than in-vivo reality. Its relationship to IP6 which inhibits adhesion is well beyond the scope of something like a gyno if that is what you are thinking.

D_