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http://www.leanbulk.com/forum A place to pose personal questions and find effective answers in regards to diet consultation, nutrition, supplement dosing etc en Sat, 21 Nov 2009 01:48:52 GMT vBulletin 60 http://www.leanbulk.com/forum/images/leanbulk/misc/rss.jpg http://www.leanbulk.com/forum http://www.leanbulk.com/forum/ask-dr-houser/9545-how-use-stack.html Thu, 19 Nov 2009 20:32:28 GMT Hello, I would like to know how to use the stack by competetive edge labs. Hello, I would like to know how to use the stack by competetive edge labs. ]]> Ask Dr. Houser luisp http://www.leanbulk.com/forum/ask-dr-houser/9545-how-use-stack.html http://www.leanbulk.com/forum/ask-dr-houser/9503-magnesium-doesnt-cause-diarrhea.html Mon, 16 Nov 2009 19:47:10 GMT Doc,

Time released magnesium oxide has been added to my fathers meds. It's giving him diarrhea, wouldn't something like magnesium malate absorb better and give less stomach problems?

P.s. he can't take potassium, it's way too high. I note this because I saw you recommend potassium magnesium chelate if I remember correctly. ]]> Ask Dr. Houser keyser http://www.leanbulk.com/forum/ask-dr-houser/9503-magnesium-doesnt-cause-diarrhea.html http://www.leanbulk.com/forum/ask-dr-houser/9496-your-book-out-yet.html Mon, 16 Nov 2009 00:29:21 GMT dinoiii just wondering if you ever published your book and if so where can we find it and if not? dinoiii just wondering if you ever published your book and if so where can we find it and if not? ]]> Ask Dr. Houser Al Swearengen http://www.leanbulk.com/forum/ask-dr-houser/9496-your-book-out-yet.html http://www.leanbulk.com/forum/ask-dr-houser/9493-zma.html Sun, 15 Nov 2009 15:41:52 GMT I bought a zma product from proven products...Now I always thought zma was zinc,magnesium,and b6...yet, thier product contains no b vitamins of any... I bought a zma product from proven products...Now I always thought zma was zinc,magnesium,and b6...yet, thier product contains no b vitamins of any kind.
I posted in thier forum about why they may hev used a diff formulation but no ones posted in there in the last FEW MONTHS so its pretty dead.Anyone know How b6 works in the equation and wether its an impotrant part??? ]]> Ask Dr. Houser donkeykong http://www.leanbulk.com/forum/ask-dr-houser/9493-zma.html http://www.leanbulk.com/forum/ask-dr-houser/9487-hmb-critical-tool-hardcore-bodybuilder.html Sat, 14 Nov 2009 02:11:29 GMT I found this article on HMB in the October 2009 issue of Natural Muscle. What is everyones opinion on this supp? ... I found this article on HMB in the October 2009 issue of Natural Muscle.

What is everyones opinion on this supp?

http://74.125.47.132/search?q=cache:...&ct=clnk&gl=us

The HMB Controversy: If, how, and for whom it may benefit

Jacob M. Wilson, M.S., PhD Candidate, CSCS

One of the more controversial supplements in industry is Beta-hydroxy-beta methylbuytrate (HMB). I have done an extensive amount of research on HMB. In fact in my 3 years at FSU I have published two papers in the journal of Nutrition and Metabolism (Wilson, Wilson et al. 2008; Wilson 2009) on the subject, and also discussed it in a manuscript in the journal of Nutritional Biochemistry(Kim, Wilson et al. 2009)#. I have also had the opportunity to speak on the subject internationally with my brother Gabriel Wilson(Wilson and Wilson 2008). Finally in terms of laboratory experience I have completed two studies on the supplement, and am in the process of finishing two more looking at what genes HMB may regulate. Thus, the readers of natural muscle will have a unique perspective on what I feel is one of the most critical supplements for bodybuilders.

What is HMB?

After consuming a meal protein synthesis is elevated, and protein breakdown is lowered. Years of research indicate that 80 % of the stimulatory effect on protein synthesis is regulated by the protein or amino acid content in that meal. Of the 20 amino acids however, the primary one essential for this effect is the branched chain amino acid leucine(Norton and Wilson 2009). Leucine is therefore perhaps the most critical component in a bodybuilder’s diet. Even more intriguing however is that leucine appears to also lower protein breakdown. For years it was not known how this exactly occurred. What was known however was that leucine is converted to HMB. Latter scientists discovered that if this conversion is blocked then leucine’s effects on protein breakdown are inhibited. (Mitch and Clark 1984).

Only 5 % of leucine is converted to HMB, which translates to an unreasonable amount of leucine needed to be consumed in the diet to maximize HMBs effects. The efficacy of HMB supplementation has been extensively investigated in the literature. While a number of studies suggest that HMB may have the ability to promote lean mass gain and performance benefits, there are conflicting results. Enter the controversy. Subsequently we are going to show how and if HMB works for athletes, and propose possible explanations for conflicting research.

The Efficacy of HMB in Athletic Populations

In a recent publication from my brother and I(Wilson, Wilson et al. 2008), we found it necessary to divide the studies on HMB into a number of categories. This is because it is necessary to distinguish between trained and untrained individuals, as well as aerobic vs. anaerobic activities. When this is done a number of findings become clear.

The benefits of HMB in untrained athletes is well established, with only two studies (single workout studies)(Paddon-Jones D 2001; Hewitt Jennifer A 2006) in our paper showing no benefit from HMB on muscle recovery.

The real controversy centers on trained athletes. While we identified several studies in the literature supporting the efficacy of HMB in trained aerobic and weight lifting athletes, there are a number of studies which suggest otherwise.

While I certainly do not dismiss these studies, I do contend that they are limited, and more research is needed to clarify on our understanding of HMB. However prior to explaining to you exactly why I have this opinion, you need to know exactly how this supplement works.

HMB Mechanisms of Action

In a nut shell, there are three mechanisms by which HMB is purported to work (figure 1): A.) improved sarcolemma (muscle cell) integrity, B.) increased protein synthesis (building of muscle tissue), and C.) decreased muscle protein breakdown (tissue atrophy).

The most common mechanism is known as the cholesterol synthesis hypothesis. Cholesterol is an important component of the muscle cell membrane. Consequently, a damaged muscle cell, such as after exercise, may lack the ability to produce adequate cholesterol for optimal repair. Incidentally, there is evidence which suggests that HMB can be converted into the rate limiting building block for de-nova cholesterol synthesis, HMG-CoA (Nissen, Sharp et al. 2000). This should result in quicker recovery from injury.

In addition, there is recent evidence showing that HMB may inhibit the main pathway responsible for protein breakdown (Ubiquitin pathway), as well as stimulate the primary pathway responsible for muscle protein synthesis (mTOR pathway). (Baxter 2006). In short, it is suggested that HMBs protective effects will allow bodybuilders to lift heavier weights over more sets before fatiguing due to muscle damage, and they will be able to repair damage at a heightened state. This coupled with the finding that HMB increases muscle building (protein synthesis) while stopping protein breakdown make it the perfect candidate for the serious bodybuilder.

Now let’s get back to this HMB controversy in advanced lifters.

The Efficacy of HMB in Advanced Lifters Continued…

Two mechanisms by which HMB may work – protein breakdown and its ability to strengthen muscle cell integrity – suggest that HMB may only be effective when muscle damage occurs or in a situation such as calorie restriction when muscle loss is heightened. Therefore, in order to see the benefits of HMB via these mechanisms, muscle damage or heightened protein breakdown must be elicited, either by a training stimulus, or a hardcore diet. Indeed, this was supported by Dr. Nissen and colleagues (1997), who showed that HMB supplementation increased muscle mass, fat loss, and strength in lifters who did exercise, but not for those who did not exercise.

While a number of studies have shown HMB to work in advanced lifters the above reasons may explain why they do not benefit consistently from HMB, in comparison to novice lifters. You see, there is a phenomenon known as the “repeated bout effect.” Essentially, the more you train, the more resistant your muscles become to being damaged (Nosaka, Sakamoto et al. 2001). Therefore, if experienced bodybuilders and lifters are to benefit from HMB supplementation, they must commit enough muscle damage, by continually overloading their muscles and changing up their rep, and set schemes. Incidentally, our paper identified a lack of variable training in several of the routines prescribed for advanced lifters who supplemented with HMB and found no benefits(Kreider, Ferreira et al. 1999). For instance, in a previous study(Kreider, Ferreira et al. 1999) advanced weight lifters were instructed to carry out their usual training routine while supplementing with HMB. Over 4 weeks of training and HMB supplementation, neither control nor supplemented conditions increased muscle mass, or lifted heavier in any measured lifts. If the athletes had no changes in performance measures in any condition, this suggests that they were adapted to their program, and perhaps needed to include more variation to see benefits from HMB. This is partly supported by studies which do support the efficacy of HMB supplementation for advanced resistance trained athletes (Nissen SL 1996; Panton, Rathmacher et al. 2000; Nissen and Sharp 2003). For instance, Panton et al.(Panton, Rathmacher et al. 2000) showed that 4 weeks of HMB supplementation in 20-40 year old men and women, resulted in greater fat loss (-1.1% vs. -.5%), upper body strength (7.5 vs. 5.2 kg), and LBM (1.4 vs. .9 kg) than the placebo group, regardless of sex or training experience.

Secondly, if HMB operates through effecting protein turnover (protein synthesis and degradation) such changes are typically slow, and may only be manifested over a number of months of training. Currently, the experiments on HMB are typically 4-8 weeks in duration. Such a time span may not be long enough to see changes in muscle mass.

HMB and Conditions of Muscle Wasting

There are a number of studies which indicate that HMB supplementation may be advantageous during various situations of muscle wasting. This includes bed rest(J.A. 1999), limb immobilization(Soares JMC), and caloric deficits(D.D. 1997). This is important as bodybuilders often restrict their calories prior to a contest. Therefore, HMB supplementation may help slow the normal muscle loss that occurs in such situations, saving the bodybuilder from losing their density and size on stage.

The elderly are another population known to be at risk for muscle loss. Incidentally, HMB supplementation has been shown to improve body composition, strength, and functionality in this population(Vukovich, Stubbs et al. 2001).

HMB and Health

HMB has been clearly shown to be safe and may even have health benefits(Nissen, Sharp et al. 2000). No side effects have been reported in mega doses in animals(Nissen, Fuller et al. 1994), and with 3-6 grams of supplementation in humans(Gallagher, Carrithers et al. 2000).

to be continued below ]]> Ask Dr. Houser Gravis Metallum http://www.leanbulk.com/forum/ask-dr-houser/9487-hmb-critical-tool-hardcore-bodybuilder.html http://www.leanbulk.com/forum/ask-dr-houser/9484-plasma-donations.html Fri, 13 Nov 2009 15:25:35 GMT I was wondering if anybody, specifically the doctor, could answer some questions regarding plasma donation and its effect, if any, on the body. Are... I was wondering if anybody, specifically the doctor, could answer some questions regarding plasma donation and its effect, if any, on the body. Are there any pros or cons? I know that plasma has a significant amount of protein, but I am not sure what the levels of hormones are or if the removal of 880mL of plasma has any negative effect on T levels. My reason for asking is that it has come to my attention that there is a local plasma center here, and I can make up to $55 for donating twice a week 880mL, which seems like some nice money to have on the side for supps. Any help and input is greatly appreciated. ]]> Ask Dr. Houser wingsoficarus116 http://www.leanbulk.com/forum/ask-dr-houser/9484-plasma-donations.html http://www.leanbulk.com/forum/ask-dr-houser/9483-food-allergies.html Fri, 13 Nov 2009 04:03:10 GMT Hey dr. Houser, i am not sure if i have food allergies that cause me to continually get bloated. I heard that wheat can cause bloating in some... Hey dr. Houser, i am not sure if i have food allergies that cause me to continually get bloated. I heard that wheat can cause bloating in some people. I have recently become lactose intolerant (im a 35 year old bodybuilder) and i need to know, what kind of allergy test should i ask my doctor to run. Any help would be appreciated. Thanks ]]> Ask Dr. Houser FASTEDDIE1081 http://www.leanbulk.com/forum/ask-dr-houser/9483-food-allergies.html http://www.leanbulk.com/forum/ask-dr-houser/9480-assistance-needed-today.html Thu, 12 Nov 2009 19:51:28 GMT ASSISTANCE NEEDED!

So my doctor basically justed f'ed up my whole cycle I think but in the long run it might be for the better. I went in today to see him regarding my blood test and he stated that the nurse gave me the incorrect numbers the other day over the phone, the actual levels were 5.1 Free Test out of a 31-94 Range and my LH levels were 1 out of a 2-6 range. So in a nutshell I am a woman for the time being. With that being said he wants me to go for blood work again tomorrow morning. This is where I need help!

My doctor is unfamiliar with PH and AAS so he said that even though I am on I should go for blood work and get new readings done. He is then going to meet with me on November 24th to discuss those readings. From there he is going to refer me to an endocrinologist which will most likely be sometime in mid December.

I have been taking Mdrol now for 7 days at 20mg per day. If I stop now do I need to do a PCT or is there no point considering that my LH and free test levels could not be any lower anyways? I was suppose to start PCT on December 5th. Should I just continue with the cycle and do clomid for PCT like I was planning on doing in the first place? I am not going to be seeing the endocrinologist till at least mid December and my that time I will be done my 10 days of Clomid as per HUGE's PCT suggestion. I think my doctor realized how low my levels actually were and may decide to go ahead with regular TEST injections weekly, HCG or possibly a total Hormone Replacement Therapy.

Any advice would be great! Do I keep going or stop immediately and if so what do I do for PCT if anything. If I do PCT that is going to throw off everything also though, hence why I thought continuing would be really the same thing. ]]> Ask Dr. Houser steve_o http://www.leanbulk.com/forum/ask-dr-houser/9480-assistance-needed-today.html http://www.leanbulk.com/forum/ask-dr-houser/9471-poliquins-30-45-g-fish-oil-day-huh-really.html Wed, 11 Nov 2009 16:17:38 GMT I know the guy is pretty well known, but is it neccessary for "super" saturation? And how healthy is it really to consume this much in a day?

I just wonder? ]]> Ask Dr. Houser j2048b http://www.leanbulk.com/forum/ask-dr-houser/9471-poliquins-30-45-g-fish-oil-day-huh-really.html http://www.leanbulk.com/forum/ask-dr-houser/9468-tauroursodeoxycholic-acid-tudca.html Wed, 11 Nov 2009 10:38:41 GMT Worthwhile to heal past liver damage??? Thanks. Worthwhile to heal past liver damage??? Thanks. ]]> Ask Dr. Houser BillCutting http://www.leanbulk.com/forum/ask-dr-houser/9468-tauroursodeoxycholic-acid-tudca.html http://www.leanbulk.com/forum/ask-dr-houser/9461-dr-opinion-egg-yolks-type-i-diabetes.html Tue, 10 Nov 2009 19:21:34 GMT Dr. Houser, What is your opinion on egg yolks and Type I diabetes? I usually eat 3-4 eggs a day sometimes all of them being yolks is this a bad... Dr. Houser,

What is your opinion on egg yolks and Type I diabetes? I usually eat 3-4 eggs a day sometimes all of them being yolks is this a bad idea? I've seen research showing trans fats and saturated fats are the main concern just wanted to get your opinion.

Also is there any service where you offer advice on diet and supplementation? If so I'd be very interested.

Thanks! ]]> Ask Dr. Houser Amino89 http://www.leanbulk.com/forum/ask-dr-houser/9461-dr-opinion-egg-yolks-type-i-diabetes.html http://www.leanbulk.com/forum/ask-dr-houser/9454-doc-whats-your-take-hgh-products.html Mon, 09 Nov 2009 23:05:47 GMT As the feds wage war on the supplement industry the next wave of androgenic products apppear to be those intended to increase GH. From everything I... As the feds wage war on the supplement industry the next wave of androgenic products apppear to be those intended to increase GH. From everything I have read IGF-1 is contraindicated in nearly every form of cancer. I'm not sure if this is a cause or effect relationship. Moreover, I'm wary of messing around with my dopamine receptors. Doc, I was just wondering if you have an opiion on these type of products? ]]> Ask Dr. Houser pdelta http://www.leanbulk.com/forum/ask-dr-houser/9454-doc-whats-your-take-hgh-products.html http://www.leanbulk.com/forum/ask-dr-houser/9449-how-do-progestins-work.html Mon, 09 Nov 2009 16:07:15 GMT Doc, Can you provide a brief (not to technical) explanation of how progestin’s work. They are very popular now days and seem to be used for lean... Doc,

Can you provide a brief (not to technical) explanation of how progestin’s work. They are very popular now days and seem to be used for lean mass gains. They have a reputation for causing gyno problems but from everything I have read they are prostate friendly. They are sometimes used to treat prostate cancer. To me this seems to be a contradiction since most gyno and prostate related issues are from estrogen dominance. ]]> Ask Dr. Houser pdelta http://www.leanbulk.com/forum/ask-dr-houser/9449-how-do-progestins-work.html http://www.leanbulk.com/forum/ask-dr-houser/9428-hernia.html Sun, 08 Nov 2009 03:25:31 GMT right off the bat, i know that i should be seeing a doctor right off the bat, but i don't have insurance and i figured i would check in here first.

to sum things up, i've had what i think is a "sports hernia" for a few months now, i haven't been lifting. at the time i was doing a lot of farm work, involving twisting and bench over position which i have read is common for sports hernias or whatever you'd like to call them. basically the main symptoms were swollen lymph nodes, mainly in the affected side, and an internal pain in the grown which has since subsided for the most part, although i'm still feeling symptoms.

basically my question is at what point is it 100% positive i have a hernia? i don't have any lumps that can be pushed back in, the closest thing is what feels like a swollen lymph node in the right side of my groin area.

also, if i DO go into the doctor, should i try to get an affordable insurance plan first? i'm assuming they would be doing x-rays, which would probably cost a lot of money without insurance.

thanks for any advice ]]> Ask Dr. Houser JesseHolmz http://www.leanbulk.com/forum/ask-dr-houser/9428-hernia.html http://www.leanbulk.com/forum/ask-dr-houser/9425-hypertension.html Sat, 07 Nov 2009 16:49:24 GMT As of late I have had an extreme amount of stress due to 1)Job and 2) Gf...long story short the bitch went psycho. Anyways I was at Wal Mart the... As of late I have had an extreme amount of stress due to 1)Job and 2) Gf...long story short the bitch went psycho. Anyways I was at Wal Mart the other day and I am on the border of pre-hypertension. I have not done too much research on this but I was curious that this could potentially be due to PHs etc. Partially? I will have to keep an eye on it to see what happens over the next few weeks. But is there anything you can take over the counter to lwer your blood pressure and Systolic/Diastolic pressure? ]]> Ask Dr. Houser blackthorns45 http://www.leanbulk.com/forum/ask-dr-houser/9425-hypertension.html