Quote:
Originally Posted by PozzSka
I grew up chubby as well. I haven't touched milk in years.
What are your goals? Fat loss, weight gain?
For fat loss i would say skip it. It is very insulinogenic, so releasing tons of insulin. Not great for fat loss.
For weight gain, it may be ok for you due to the increases in IGF-1 it causes. But, that effects all tissue, muscle, fat, bone etc.
he talks about a bunch of stuff, but he mentions the increase in IGF-1 due to milk intake.
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This is interesting.
It seems a bbing lifestyle would accelerate ageing in numerous ways. Anabolic pathways seem to accelerate it (like insulin/IGF-1, mTOR, etc) while those associated with atrophy of muscle and oxidative phenotypes (endurance exercise) slow ageing in animal models. This includes the FOXO, sirtuins, PGC-1alpha (master regulator of mitochondria biogenesis) etc pathways (which are all linked in various ways).
Resveratrol, caloric restriction, and (endurance) exercise all use the latter pathway and extend lifespan pretty significantly in lower animal models, as well as preventing many ageing related diseases like cardiovascular disease, osteoporosis, alzheimers, etc
Off hand I know creatine increases plasma IGF-1, as well as TRPV1 ligands (capsaicin, raspberry ketones, etc). Any AAS would obviously do this as well.
Course free IGF-1 to bound IGF ratios are also significantly effected by diet and fat ratios.
The question that need to be answered is to what relevance is all of this to humans. I am betting bodybuilders on average have significantly lower lifespans.