Forskolin during PCT

[GotTest]

Getting ready for my month of "Drive" by App Nut and noticed it contains Forskolin.

I've heard nothing but EXCELLENT reports about Drive, so I did a little reading up on this compound in particular and it has been credited for, "one of the best compounds available for triggering dramatic increases in cAMP levels. One study (Bristow et al, 1984) showed that forskolin was able to increase cAMP levels 4.82 times more than a placebo."... "high cAMP levels also equate to high levels of luteinizing hormone (the hormone responsible for mediating endogenous spermatogenesis), and when cAMP levels are elevated (DRIVE causes a marked elevation of cAMP), it serves as an intermediate in the signaling cascade that ranges from luteinizing hormone (LH) binding to testosterone production."

My first thought was, "This sounds GREAT for supplementing PCT to help get things back in "full swing".

The research quoted seems old, so I was wondering what you had in your database regarding Forskolin and your thoughts for use in PCT.

[dinoiii]

How bout

Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 13(8): 1335-1343. 2005.

Not only was fat loss better suited with supplemental forskolin groups...BUT there was also a trend toward an increase in lean body mass in the forskolin group and when compared to the placebo group...free testosterone was increased significantly. The change in serum total test was not significantly different between the groups, but free test increased 17% in the forskolin group while decreasing 1% in the placebo setting.

Bottom Line: The boys from AN knew what they were doing with the construction of Drive - perhaps not noted in their write up, BUT still decent end product.


This is part of a featured stack in the 3rd issue of the Clinical Underground and I would beg that you NOT miss out on this - it is non-hormonal and set up to kick your lean mass gains through the stratus fear.

Like the Prudent Cut Cycle's (PCCs) before it; this is entitled the first Prudent Mass Cycle (PMC). Check it out - sent out on January 3, 2008 (about 3 weeks away).


D_

[GotTest]

Hooyah!
Great news Doc, Can't wait to start the "Drive" (and fat loss to boot)!


Wouldn't dare miss the next issue of CU either.
3 weeks and counting...

[Right Hook]

There seems to be a lot of good feedback on forskolin/forslean. It seems though that there are some issues with oral bioavailability? Is this addressed in the upcoming CU?

Also Par Dues made a post back in 04:

Forskolin/cAMP and androgens have some really interesting tie-ins.

For instance, it causes AR independent induction of androgen response element, but at the receptor, it decreases signalling, by inhibiting phosphorylation.

In the testes, it has been found to have a inverted U shaved dose-response curve, in vitro, with low and high concentraions inhibiting test production, and a moderate concentration increasing it.

How all of this plays in the world, I haven't a clue. I tend to think it would decrease activity slightly, if anything.

His post makes me wonder how does one define a "moderate concentration" especially in a product like Drive that includes the forslean into a propietary forumula.

[thesinner]

There's been a few studies comparing forskolin to anavar on body composition. Granted there's some things to take into consideration when comparing a non-AAS to AAS, I still find it to be quite interesting.

[Right Hook]

Originally Posted by thesinner

There's been a few studies comparing forskolin to anavar on body composition. Granted there's some things to take into consideration when comparing a non-AAS to AAS, I still find it to be quite interesting.

Hopefully its not as bad on the lipids.

[GotTest]

Originally Posted by thesinner

There's been a few studies comparing forskolin to anavar on body composition. Granted there's some things to take into consideration when comparing a non-AAS to AAS, I still find it to be quite interesting.

The first thing I think of when it comes to comparing NonAAs to AAS is MARKETING HYPE (which is why I was curious about the research).

Trib was always credited to increase LH/Test levels but Trib never really impressed me even at relatively higher doses. I was dosing HyperTest at 6caps/day, with no real "feeling" of increased Test.
Though "Drive" is a blend with Forskolin, I'm hoping for a better experience than I did with other herbals like Hypertest.

[thesinner]

Originally Posted by Travis

Hopefully its not as bad on the lipids.

Originally Posted by GotTest

The first thing I think of when it comes to comparing NonAAs to AAS is MARKETING HYPE (which is why I was curious about the research).

Trib was always credited to increase LH/Test levels but Trib never really impressed me even at relatively higher doses. I was dosing HyperTest at 6caps/day, with no real "feeling" of increased Test.
Though "Drive" is a blend with Forskolin, I'm hoping for a better experience than I did with other herbals like Hypertest.

There's a lot to be said about this sort of research, and yeah, I first read about it in just that, marketing hype (for Biotest's Carbolin).

As I was alluding to in my previous post, this type of research needs to be taken with a grain of salt. Forskolin works through pretty much a totally different mechanism than AAS. Comparing anabolics to sex, if AAS was the missionary position, forskolin would be some weird thing that people only do in the porn industry (and would likely invlove a midget, abnormal body parts, and extreme flexibility).

There are many different factors to be taken into consideration, such as dosages, training, and diet.

The same overhyped thing happened with ecdysterone a few years ago, after a few studies showed that it did some things better than dianabol. Then the ads came out saying things like "Better than Dbol and without the sides!". Such a gross generalization caused....well.....the current general consensus.

Another point to mention (GotTest) is that while Trib is a plant (a shrubbery I believe), forskolin is a phytochemical. Plants have many different phytochemicals (phytochemical = chemical present in plant); hence, this leaves a lot of room for error.

[dinoiii]

Originally Posted by Travis

There seems to be a lot of good feedback on forskolin/forslean. It seems though that there are some issues with oral bioavailability? Is this addressed in the upcoming CU?

This will NOT be addressed in the CU actually. Understand that the promoted effects (increased cAMP) is what is called to question with bioavailability studies - simply because the intracellular cAMP tallies have been less than stellar. The testosterone-related effects have been supported by in vivo data (see my next response).

His post makes me wonder how does one define a "moderate concentration" especially in a product like Drive that includes the forslean into a propietary forumula.

Unsure how he defined it as I believe he has been quoted out of context which sometimes presents itself as a challenge.

In any event, the study that showed results used 250mg of a 10% forskolin extract if you are curious.


D_

[Right Hook]

Originally Posted by dinoiii

How bout

Godard MP, Johnson BA, Richmond SR. Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men. Obes Res. 13(8): 1335-1343. 2005.

Not only was fat loss better suited with supplemental forskolin groups...BUT there was also a trend toward an increase in lean body mass in the forskolin group and when compared to the placebo group...free testosterone was increased significantly. The change in serum total test was not significantly different between the groups, but free test increased 17% in the forskolin group while decreasing 1% in the placebo setting.

Bottom Line: The boys from AN knew what they were doing with the construction of Drive - perhaps not noted in their write up, BUT still decent end product.


This is part of a featured stack in the 3rd issue of the Clinical Underground and I would beg that you NOT miss out on this - it is non-hormonal and set up to kick your lean mass gains through the stratus fear.

Like the Prudent Cut Cycle's (PCCs) before it; this is entitled the first Prudent Mass Cycle (PMC). Check it out - sent out on January 3, 2008 (about 3 weeks away).


D_

Any idea what the dosing was in that study? Of forskolin that is...