SAM-e and Prolactin

[Owen70]

Int Clin Psychopharmacol 1987 Apr;2(2):97-102

The influence of S-adenosylmethionine (SAM) on prolactin in depressed patients.

Thomas CS, Bottiglieri T, Edeh J, Carney MW, Reynolds EH, Toone BK

Twenty subjects entered a double-blind placebo-controlled trial of SAM in
depression. Prolactin concentrations were measured before and after 14 days'
treatment. There was a highly significant fall in prolactin concentrations in
the SAM-treated group.

OR/AND

J Psychiatr Res 1990;24(2):177-84

Neuroendocrine effects of S-adenosyl-L-methionine, a novel putative
antidepressant.

Fava M, Rosenbaum JF, MacLaughlin R, Falk WE, Pollack MH, Cohen LS, Jones L,
Pill L

Clinical Psychopharmacology Unit, Massachusetts General Hospital, Harvard
Medical School, Boston 02114.

S-adenosyl-L-methionine (SAMe), a putative antidepressant, is a naturally
occurring substance whose mechanism of action is still a matter of speculation.
It has been recently postulated that SAMe may increase the dopaminergic tone in
depressed patients. Since dopamine inhibits both thyrotropin (TSH) and
prolactin secretion, we investigated the effects of treatment with SAMe on the
TSH and prolactin response to thyrotropin-releasing-hormone (TRH) stimulation
in 7 depressed outpatient women (mean age: 46.1 +/- 7.2 years) and 10 depressed
outpatient men (mean age: 38.0 +/- 10.0 years) participating in a six-week open
study of oral SAMe in the treatment of major depression. At the end of the
study, there was a significant reduction after treatment with SAMe in the
response of both prolactin and TSH to TRH stimulation in the group of depressed
men compared to pre-treatment values. On the other hand, in the group of
depressed women, the posttreatment prolactin response to TRH did not appear to
change when compared to pre-treatment and the TSH response to TRH challenge
tended even to augment slightly after treatment with SAMe. Our results, at
least in depressed men, seem to support the hypothesis of a stimulating effect
of SAMe on the dopaminergic system.

Now is it going to be a strong effect so that cabergoline and its ilk can be replaced in the setting of prolactin-induced gyno prevention?
Lord i need more time to read
P.S. if you want the second studies full text dinoiii, i can send it to you

[dinoiii]

Hey Owen,

There are two suggested mechanisms at work here:

[1] SAMe does upregulate dopaminergic systems (which is cited effectively by the second study authors) and as I am certain many of you recall...dopamine acts as an inhibitory molecule on Prolactin secretion.

-and-

[2] There is a estrogen inhibitory effect of SAMe. Recall, high circulating estrogen concentrations do, in effect, promote prolactin secretion - which we know happens with many of the gentlemen coming out of a highly-suppressive cycle.





The distinction between cabergoline and SAMe in regards to stimulation of the dopaminergic system (and subsequently prolactin inhibition and/or antidepressant actions) is really summed up with this basic thought:

SAMe: improves dopamine receptor site binding; quick onset and short-acting

Cabergoline (Dostinex): dopamine agonist; quick onset BUT long-acting


So, an effective answer to your question is NO - it isn't exactly the same nor will it likely provide the same level of prolactin inhibition. What I could see happening is starting someone with prolactin-induced gyno etc... with Cabergoline and transferring them into SAMe dosing. SAMe "may" aid cabergoline binding overall, but this is really unclear at this point. This will likely show up in future research for sure.


D_

[Owen70]

Originally Posted by dinoiii

Hey Owen,

There are two suggested mechanisms at work here:

[1] SAMe does upregulate dopaminergic systems (which is cited effectively by the second study authors) and as I am certain many of you recall...dopamine acts as an inhibitory molecule on Prolactin secretion.

-and-

[2] There is a estrogen inhibitory effect of SAMe. Recall, high circulating estrogen concentrations do, in effect, promote prolactin secretion - which we know happens with many of the gentlemen coming out of a highly-suppressive cycle.





The distinction between cabergoline and SAMe in regards to stimulation of the dopaminergic system (and subsequently prolactin inhibition and/or antidepressant actions) is really summed up with this basic thought:

SAMe: improves dopamine receptor site binding; quick onset and short-acting

Cabergoline (Dostinex): dopamine agonist; quick onset BUT long-acting


So, an effective answer to your question is NO - it isn't exactly the same nor will it likely provide the same level of prolactin inhibition. What I could see happening is starting someone with prolactin-induced gyno etc... with Cabergoline and transferring them into SAMe dosing. SAMe "may" aid cabergoline binding overall, but this is really unclear at this point. This will likely show up in future research for sure.


D_

thanks dana,
did you get the email i sent you from jowen88@gmail.com about prolactin and trenadrol?

[Voodoo]

Originally Posted by dinoiii

So, an effective answer to your question is NO - it isn't exactly the same nor will it likely provide the same level of prolactin inhibition. What I could see happening is starting someone with prolactin-induced gyno etc... with Cabergoline and transferring them into SAMe dosing. SAMe "may" aid cabergoline binding overall, but this is really unclear at this point. This will likely show up in future research for sure.


D_

Why do I have a feeling that I am the future research as Im the one noted for this case most often.... I dont like where this is going lol

[dinoiii]

Originally Posted by Owen70

thanks dana,
did you get the email i sent you from jowen88@gmail.com about prolactin and trenadrol?

Have to check on that. Since my sister's incident I have been a bit more backed up in the email dept., but this should start to even itself out now that she is becoming more responsive.

Originally Posted by Voodoo

Why do I have a feeling that I am the future research as Im the one noted for this case most often.... I dont like where this is going lol

Well, your signature implies you are opt for "guinea pig" status, no?


D_

[Voodoo]

Originally Posted by dinoiii

Well, your signature implies you are opt for "guinea pig" status, no?


D_

so long as our collective learning curve is reversable.

[dinoiii]

Originally Posted by Voodoo

so long as our collective learning curve is reversable.

point taken.





[holds off on year supply shipment of SAMe to Voo...]


D_