Old 02-25-2008, 06:22 PM   5 links from elsewhere to this Post. Click to view. #1
 
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Default new resveratrol study on testosterone
this is done by different researchers that did the spanish study


1: Arch Pharm Res. 2008 Jan;31(1):83-7.Links
trans-Resveratrol relaxes the corpus cavernosum ex vivo and enhances testosterone levels and sperm quality in vivo.Shin S, Jeon JH, Park D, Jang MJ, Choi JH, Choi BH, Joo SS, Nahm SS, Kim JC, Kim YB.
College of Veterinary Medicine, Chungbuk National University, Heungdeok-gu, Cheongju, Chungbuk 361-763, Korea.

We examined the effects of trans-resveratrol on male reproductive functions; ex-vivo penile erection and in-vivo sperm counts and quality. For the ex-vivo study, the relaxation effects of resveratrol on isolated New Zealand white rabbit corpus cavernosum, precontracted by phenylephrine (5x10(-5) M) were measured. The in-vivo study measured reproductive organ weights, blood testosterone levels, testicular histopathology, sperm counts, as well as the epididymal sperm motility and deformity of male ICR mice given an oral dose of resveratrol (50 mg/ kg) for 28 days. Resveratrol elicited a concentration-dependent relaxing effect on corpus cavernosum, leading to a median effective concentration (EC50) of 0.29 mg/mL. Repeated treatment with resveratrol (50 mg/kg) did not cause an increase in body weight, reproductive organ weight or testicular microscopic findings; however, resveratrol did elicit an increase in blood testosterone concentration, testicular sperm counts and epididymal sperm motility by 51.6%, 15.8% and 23.3%, respectively, without influence on sperm deformity. In conclusion, we propose that resveratrol has a positive effect on male reproductive function by triggering a penile erection, as well as enhancing blood testosterone levels, testicular sperm counts, and epididymal sperm motility.

PMID: 18277612 [PubMed - in process]

Thoughts???

Posted by PA at BB.com
Old 02-25-2008, 06:29 PM   #2
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My thought is good stuff. I still believe this is just the begginning.....I know D_ isnt on the bandwagon yet. But the SIRT's are interesting...
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Old 02-25-2008, 06:59 PM   #3
 
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my personal experience:one full month on 1000mg/day 98% resveratrol(transmax).testosterone in the 800's.exactly as usual for me.
Old 02-25-2008, 07:24 PM   #4
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Why does nobody consider phenotype??
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Old 02-25-2008, 07:57 PM   #5
 
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How can I say this without being deemed a complete a$$ (ok, deem it what you may)?

I am not sure most people understand phenotype Colby.

But besides that...Did anyone happen to see the use of 50mg/kg which translates into 4545mg (4.5 grams) for a 200-pound human WITHOUT dose-adjustment upward, which translates into a much higher volume-of-distribution estimate for a human anyway (which is something we knew and NO supplement has that kind of concentration)?

Not to mention, the pre-contraction with phenylephrine. The study is worthless for extrapolative purposes.


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Old 02-25-2008, 08:23 PM   #6
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Quote:
Originally Posted by GeneGnome View Post
Why does nobody consider phenotype??
Quote:
Originally Posted by dinoiii View Post
How can I say this without being deemed a complete a$$ (ok, deem it what you may)?

I am not sure most people understand phenotype Colby
D_
I certainly dont understand. Stuff like that I would assume is beyond the knowledge of the average consumer (me).


Phenotype - Wikipedia, the free encyclopedia
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Old 02-25-2008, 11:39 PM   #7
 
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Quote:
Originally Posted by GeneGnome View Post
Why does nobody consider phenotype??

LOL I don't know what that is.


Quote:
Originally Posted by dinoiii View Post
How can I say this without being deemed a complete a$$ (ok, deem it what you may)?

I am not sure most people understand phenotype Colby.

But besides that...Did anyone happen to see the use of 50mg/kg which translates into 4545mg (4.5 grams) for a 200-pound human WITHOUT dose-adjustment upward, which translates into a much higher volume-of-distribution estimate for a human anyway (which is something we knew and NO supplement has that kind of concentration)?

Not to mention, the pre-contraction with phenylephrine. The study is worthless for extrapolative purposes.


D_
I noticed that and someone else noticed it at bb.com. Disheartening to say the least esp at my current weight.

Thanks for the input D, this is why I come to u before getting to amped about something hehe.
Old 02-25-2008, 11:55 PM   #8
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I mean, res induces a highly oxidative phenotype in lower organisms... not what a person going for max size would want (remodels fibers toward slow instead of fast).
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Old 02-26-2008, 01:25 PM   #9
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Quote:
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Why does nobody consider phenotype??
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Old 09-17-2009, 10:49 PM   #10
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resveratrol really has a lot of health benefits aside from Anti-Aging,Cardiovascular Health,Anti-Inflammatory, and many more.
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