Did I get it?

[Caiolgn]

I’ve been reading through some posts here at leanbulk, especially Ask Dr. Houser section, where I found some very good info. Unfortunately, there are some topics which I didn’t understand yet, and I would like Docs suggestion on some issue. Sorry Dr. but I found some of your posts rather confusing, not getting straight to the point, etc… I think everyone could learn a bit with this post, and you always encourage everyone to ask so here I am :D

DATA

PREVIOUS BLOODWORKD (let me know if you need more data, I can post them here)

Lipid Panel:
Total cholesterol: 144mg/dl
HDL cholesterol: 42mg/dl (always had this kinda low)
LDL cholesterol: 91mg/dl
Triglycerides: 53mg/dl

Creatinine: 1.1mg/dl

TGO: 34U/L
TGP: 37U/L

LH: 4.0mUI/ml
Total test: 638ng/dl (Unfortunately don’t have free test)

Stats:
23 years old
1.80meters height
82kg
10%BF

Had some previous experience with deca + sostonol 250 + turinabol

I’m planning to do the following cycle (objective: lean mass)

Week 1-8: 3 Sostonol 250mg/week
Week 1-4: Trenbolone Acetate 75mg eod
Week 1-4: Oral Turinabol 70mg ed

Support Supps:
AI Life Support: 4 caps everyday during the entire cycle
HCG: 1500ui twice a week during the entire cycle

Post Cycle Therapy: (10 days after last shot)
For the first 5 days: Clomid 50mg; For the remaining 16 days: Clomid 25mg (Total: 3 weeks under clomid)
SAMe: Week1: 600mg, Week2: 600mg, Week3: 400mg
I3C: Week1: 400mg, Week2: 200mg: Week3: 200mg
AIs: Lost on this one, anyways: Anastrozol: Week1: 0,25mg, Week2: 0,5mg, Week3: 1mg Week 4: 0,5mg, Week5: 0,25mg, Week 6: 0,25mg every 2 or 3 days

Remembering that I have already adopted some of your supplement recommendations:

ACES + BComplex + MultiMineral + Magnesium Citrate / Zinc Polinicotinate
Fatty Acids Recommendations
Alcar (2-3grams/day)

QUESTIONS

[1] Should I use clomid for 4 weeks instead of 3? Would it be beneficial to start with a higher dose (like 100mg) then tapering it down?
[2] Wouldn’t be wise to use I3C DURING cycle to optimize estrogen metabolism since I’m using test? Also, I tapered it down because of the AI’s dosage scheme, there will be no estrogen to metabolize as the dosage goes up, right?
[3] SAMe during cycle isn’t a good ideia? Sorry for asking things about “on cycle”, because your main article (PCT: A Clinician's View Part) focused only on PCT
[4] About AIs, this is where I’m completely lost. You seem to recommend an increasing dosage like the one I stated, but why? Did I get something wrong? Wouldn’t some estrogen be beneficial for lipid values, IGF-1, libido, etc..? Why don't start with a high dose then lower it as the time goes? What about aromasin/exemestane/letrozole? I know the difference between them, but which one do you recommend and why?
Also, considering that I will be coming off an aromatisable steroid and lots of estrogen will be present, wouldn't it be wise to start with a high dose AI (to bring the estrogen suppression over HPTA down) and then taper it down? Then the dosing scheme wtih I3C would change as well, starting with a lower dose and then going up?
[5] About the HCG dosage, is something wrong? Should I stop using it on the last week?
[6] What about using GH/IGF-1 on the PCT? Not only Clomid decreases IGF-1 values, but it seems that this hormone may play some role at leydig cell differentiation
(Development of Leydig Cells in the Insulin-Like Growth Factor-I (IGF-I) Knockout Mouse: Effects of IGF-I Replacement and Gonadotropic Stimulation
Guimin Wang, and Matthew P. Hardy2)
[7] Maybe I should add an extra week for my PCT?
[8] Urtica Dioica solely use is for BPH? What about to counteract the rise in SHBG caused my clomid?

[broken7]

Thats way to much hcg for use during the cycle.

[dinoiii]

Originally Posted by broken7

Thats way to much hcg for use during the cycle.

Haven't read too much of this thread at this point due to significant detail and time limitations, but I would be inclined to agree, UNLESS a baseline dose of hCG is used on a daily basis which provides some with success.

My concern would be cost efficiency versus overt efficacy though. In other words, would taking say 250 IUs daily be inferior to 250IUs every other day while on cycle - I am afraid this hasn't been answered objectively at present, though both appear to do ok for prevention of testicular atrophy, possibly suggesting successful therapy (unclear).


D_

[Caiolgn]

Originally Posted by dinoiii

Haven't read too much of this thread at this point due to significant detail and time limitations, but I would be inclined to agree, UNLESS a baseline dose of hCG is used on a daily basis which provides some with success.

My concern would be cost efficiency versus overt efficacy though. In other words, would taking say 250 IUs daily be inferior to 250IUs every other day while on cycle - I am afraid this hasn't been answered objectively at present, though both appear to do ok for prevention of testicular atrophy, possibly suggesting successful therapy (unclear).


D_

Why is it too much? Are you saying that because you observed that more than 250ui everyday / every other day has no benefit versus a larger dose like 1500ui 2x a week? Or that 1500ui could cause potential side effects? (gyno maybe?)
Cost is of no issue for me, I can get HCG very cheap here
The biggest problem would be using 250ui, as the size of the ampoule being sold here is 5000ui (1ml). Maybe an insulin syringe can do it, but I don't know if I can store the remaining of the solution without losing its efficacy. Oh and I need to keep it under 6C either, and I definitely cannot store HCG in the fridge of my house

Thanks for the advice. Waiting for your response on the other questions

[broken7]

Too high a dose of hcg for too long could damage the leydig cells, thats what I hear at least. Doc would know more.
If you can't store the hcg in your fridge then you might be SOL for using it during the cycle. Maybe you could just use it post cycle or near the end of cycle.

[dinoiii]

As for hCG dosing; taking too much could actually desensitize the Leydig cell (I am unsure about overt "damage" per se), making it that much longer to return to your baseline functioning, which kind of eliminates rationale to take it in the first place.

As for your other questions; I am actually doing my best to get to as many as I can in this highly transitional time, you just happened to ask quite a few that time dosen't usually permit it; not to mention follow-up questions to what I end up answering (what's funny is some people say I tend to write too much still and when I try and shorten them, others get upset about the length as well, and it leads to many more follow-ups).


D_

[Caiolgn]

Originally Posted by dinoiii

As for hCG dosing; taking too much could actually desensitize the Leydig cell (I am unsure about overt "damage" per se), making it that much longer to return to your baseline functioning, which kind of eliminates rationale to take it in the first place.

As for your other questions; I am actually doing my best to get to as many as I can in this highly transitional time, you just happened to ask quite a few that time dosen't usually permit it; not to mention follow-up questions to what I end up answering (what's funny is some people say I tend to write too much still and when I try and shorten them, others get upset about the length as well, and it leads to many more follow-ups).


D_

I shall then lower the dose to 500IU twice a week. That's ok I suppose?

There is no need to hurry, being a Doc must be quite time consuming. Oh, and I have absolutely no problems with long answers . Actually, I would be glad if you could detail your answers as much as possible

thanks in advance

[Caiolgn]

Another question about AIs

Suicide inhibitors: not necessary do to the ramp down because it will attach irreversibly to the enzyme. Newly synthesized enzymes will gradually put estrogen back in, without an abrupt change. Not the same can be told for non-suicide inhibitors

Is the above statement true?

[Caiolgn]

bump for D