Growth Hormone: What it is and why levels deteriorate with age / Semorelin GH-RH

[Gixxer82]

Originally Posted by scruffy the cat

what is semorelin ? some kind of gh releaser? my hrt doc is all about it !

Taken from Testosterone Therapy & Medical Weight Loss Clinic

Growth Hormone Releasing Hormone (GHRH) Therapy Sermorelin Acetate for Subcutaneous Injection - GH-RH (1-29)


Growth hormone deficiency in adults occurs when the naturally occurring pituitary hormone known as human growth hormone is produced in inadequate quantities with a resulting deficiency in growth hormone and IGF-1 levels. Growth hormone deficiency includes a spectrum that ranges from a complete lack of growth hormone through various degrees of partial growth hormone deficiency.

In contrast to supplementing the growth hormone deficiency through injections of exogenous recombinant human growth hormone (HGH), GH-RH therapy involves the use of GH-RH injections that cause the body’s pituitary gland to secrete greater quantities of naturally produced human growth hormone. The body therefore naturally produces its own growth hormone to supplement the deficiency as a result of GH-RH therapy.

Semorelin is the acetate salt of an amidated synthetic amino acid polypeptide, consisting of the first 29 of 44 amino acids of naturally occurring human growth hormone-releasing hormone (GH-H). Semorelin acetate is the last of the hypothalmic-releasing hormones to be identified and characterized, and represents the shortest fragment of GH-RH known to possess the full biological activity of the parent hormone.

In contrast to increasing growth hormone levels by the injection of biosynthetic human growth hormone, GH-RH injections increase plasma growth hormone concentrations in patients with idiopathic growth hormone deficiency by directly stimulating the pituitary gland to release natural human growth hormone. Semorelin acetate for injection (GH-RH ) is similar to natural GH-RH with respect to its ability to stimulate growth hormone secretions in humans.

GH-RH for injection has been effective in the treatment of growth hormone deficiency in children. The clinic anticipates that GH-RH will also be effective in the treatment of adult growth hormone deficiency because it has been effective in the treatment of children, and because HGH has already proven itself to effective in cases of adult growth hormone deficiency. The GH-RH used by the clinic has been studied for 12 years in more than 70 clinical trials in over 2,600 child patients totaling more than 485 patient years of treatment.

Growth hormone releasing hormone for injection was approved for use with children by the FDA in 1997 and became available to the clinic in 1998. It is an experimental clinic treatment with regards to adult patients who are prescribed about half the dose of a small child. Prior clinic approval is required to participate in the adult clinical trial program conducted by the clinic. This therapy has great potential for adults who have growth hormone deficiency and seek to reverse the effects of aging or treat a medical disorder. A patient who is unsatisfied with the results obtained through GH-GH therapy may elect to be treated thereafter with human growth hormone (HGH) replacement therapy.

I suggest reading that whole article, some great information that is easy to understand!