Quote:
Originally Posted by Beejis60
Not a good idea due the one isomer (I think it's the alpha isomer) metabolizes into a potent anabolic thus needing a PCT for your PCT. It has not been demonstrated to me that a single 6-bromo product has pure beta isomer (assuming that the alpha isomer is the isomer that metabolizes into that potent anabolic).
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Check out this aricle
Stereochemistry of the functional group determines the mechanism of aromatase inhibition by 6-bromoandrostenedione -- Osawa et al. 121 (3): 1010 -- Endocrinology
especially, "We have found that 6 alpha-bromoandrostenedione (6 alpha-BrA) is a competitive inhibitor of human placental aromatase with respect to androstenedione..."
Also,
http://pubs.acs.org/cgi-bin/abstract...?sessid=6006l3
The end of the 2nd paragraph, "Furthermore,
both 6a- and 6b-bromoandrostenedione are competitive
inhibitors of androstenedione aromatization, as determined
by a Lineweaver-Burk plot, and 6a-bromoandrostenedione
gives the same type I cytochrome P-450 binding
spectrum with placental microsomes as androstenedione. These
data suggest that 6a-bromoandrostenedione is effective as an
active-site-directed inhibitor of placental microsomal aromatase"
PA just wants you to believe that 6-OXO is the ONLY solid OTC AI...Oh wait does Ergopharm make that product??
