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Old 10-10-2007, 03:58 AM   #1
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Default Interesting study on ATD
Studies on aromatase inhibition with 4-androstene-3,6,17-trione: its 3 beta-reduction and time-dependent irreversible binding to aromatase with human placental microsomes.
Numazawa M, Tsuji M, Mutsumi A.

Tohoku College of Pharmacy, Sendai, Japan.

The metabolism of 4-androstene-3,6,17-trione (AT), previously described as a suicide substrate for aromatase, and its irreversible binding to aromatase were studied by using human placental microsomes. AT was rapidly converted into 3 beta-reduced metabolite (3-OHAT) with an enzyme other than aromatase in the microsomes in the presence of NADPH under either aerobic or anaerobic conditions. The conversion was efficiently prevented by a steroid 5 alpha-reductase inhibitor. 3-OHAT was characterized as a competitive (Ki = 6.5 microM) and irreversible inhibitor of aromatase. Both 14C-labeled AT and 3-OHAT were demonstrated to be irreversibly bound to aromatase probably through a sulfur atom of the enzyme in time-dependent manners in the presence of NADPH, being accompanied with time-dependent losses of the enzyme activity. It was shown that the process of an apparent time-dependent loss of aromatase activity caused by AT even under conditions allowing its 3 beta-reduction should principally depend on the action of the parent inhibitor AT itself and not on that of the metabolite 3-OHAT.
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Old 10-10-2007, 10:57 AM   #2
 
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Ever look more into this study (i.e. - beyond the abstract) RA? Be wary of funding, et al.


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Old 10-10-2007, 11:20 AM   #3
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Ever look more into this study (i.e. - beyond the abstract) RA? Be wary of funding, et al.


D_
I don't believe I have access to it, if you do and could point me in the right direction, I'd love to study further.
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Old 10-10-2007, 01:06 PM   #4
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this is the limitation on a EVERYTHING, no pubmed subscription so most of us get to read abstracts
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Old 10-31-2007, 10:19 PM   #5
 
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this is the limitation on a EVERYTHING, no pubmed subscription so most of us get to read abstracts
I have the full text, but-

Your file of 954.1 KB bytes exceeds the forum's limit of 244.1 KB for this filetype.
Old 11-01-2007, 02:53 PM   #6
 
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Quote:
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I have the full text, but-

Your file of 954.1 KB bytes exceeds the forum's limit of 244.1 KB for this filetype.
be nice if we could get this bumped to something more reasonable like 5-10MB...
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Old 11-02-2007, 11:00 PM   #7
 
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Quote:
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I don't believe I have access to it, if you do and could point me in the right direction, I'd love to study further.
Quote:
Originally Posted by B-natural View Post
this is the limitation on a EVERYTHING, no pubmed subscription so most of us get to read abstracts
I've uploaded it here

www.zshare.net/download/4632945d62f9b8

Quote:
Originally Posted by muad33b View Post
be nice if we could get this bumped to something more reasonable like 5-10MB...
Agreed, no pdf will be under 200k
Old 11-02-2007, 11:07 PM   #8
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I've uploaded it here

www.zshare.net/download/4632945d62f9b8



Agreed, no pdf will be under 200k
I'll work on that madness... someone will pay with their life... muahahah!
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Old 01-12-2008, 03:49 PM   #9
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How is a study on 6-oxo an interesting study on ATD?
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Old 01-13-2008, 02:44 PM   #10
 
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