The purpose of THIS one is to revamp the old one and bring more insight into this as there's still many a questions that need to be addressed. I will do my best to make this THE MOST COMPLETE PCT guide possible while still being understandable and easy to read. Ok so here goes!!
PCT = Post Cycle Therapy.
PCT's are used to come off of a cycle of a ph/ps/aas (prohormone/prosteroid/anabolic-androgenic steroid) cycle. A PCT's function is not only to help maintain gains, but to bring your body back to where it would naturally be, or as close to that as possible, help prevent rebound effects, and control some of the other 'bad' effects a cycle can create. A PCT can be generalized as a 'taper' back to normality.
PCT's are necessary and should not in any way be taken lightly. When starting a cycle, you should always know your PCT and have it lined up ahead of time. The number of PCT style/combos possible is limitless, and I WILL be addressing several options and possibilities in THIS thread.
Major components to be consider during the PCT timeframe are the restoration of your HPTA's functionality and the rebound of testosterone vs the decline in testosterone. The goal here is to prevent the body from trying to 'repair' itself... The key in PCT is to lower estrogen levels safely, raise testosterone (natural not exogenous), and keep other hormones in balance (ie: cortisol and thyroidal hormones on some occasions/etc). Let's walk over each step here.
Lowering Estrogen:
This will be a huge section due to the fact that there's a lot of ground to cover and lot of misconceptions. We'll start with the most basic and simple to more complicated matters, so for those of you following along who don't care to get into the nitty gritty only have to read the first part and then skim down to the next section!
OTC Anti-estrogens via Aromatase Inhibition. (please note they can be written SEVERAL different ways, I'm going basic here)
- 3,17-dioxo-etiochol-1,4,6-triene (More commonly, ATD)
- 6,17-dioxo-etiocholene-3-ol (More commonly, 3-OHAT)
- 3,6,17-AndrosteneTrione (More commonly, 6-oxo)
- 17a-methyl-17b-hydroxyl-3-keto-delta 1,4,6-etioallocholtriene
- 4-hydroxyandrostenedione (More commonly, Formestane or 4-OHAD)
I won't go into more detail with the several others available because these are the most common.
- ATD is cheap and very effective, doses of ATD usually never exceed 75mgs. ATD Can have impact on your libido.
- 3-OHAT is a bit less common, but still effective, it is known to be faster acting than ATD.
- 6-oxo is an old favorite for many, it is a suicide inhibitor (it binds to the enzyme permanently, preventing it from binding elsewhere)
- Methylated ATD which is found in AX's old version of PCT and assumingly Fast Actions Revive T, is NOT liver toxic and allows users to reap the full benefits of ATD minus the lack in libido.
- Formestane is becoming more and more popular, especially in the transdermal form which requires not only a lesser dose, but less frequent dosing.
An interesting study I found on ATD:
NON-OTC Estrogen Modulation
Selective Estrogen Receptor Modulators, more commonly SERMS.
There are several different SERMs and a lot of fuss about which ones are best and which ones arent. I won't sit here and argue about it in my thread, but I will discuss the most popular SERMs individually.
Tamoxifene; More Commonly - Nolvadex
Nolva is known very widely and used/abused in a similar sense. Nolva has a reputation as being the best because it is the most researched, however it's hepatoxicity (liver toxicity) and effects on GH are not smiled upon as much as it's effects in dealing with gynecomastia and restoring HPT axis function.
Clomiphene; More Commonly - Clomid
Clomid is known very widely as well, unfortunately a lot of people think that this is "the best" SERM in terms of restoration of the HPT axis. Clomid therapy is very well known and practiced, I personally do not side with it's usage and stay away from it.
Raloxifene; More Commonly - Evista
Ralox is known to be very beneficial to bone density, preventing/treating gynecomastia and moderately effective with the restoration of the HPTA. A common side effect is blood clots.
Toremifene; More Commonly - Fareston
Toremifine is very popular in the modern day and age due to it's very fast recovery with the HPTA and test production. It's effects on gyno are not as well studied as other SERMs.
Aside from the SERM realm there are also NON-OTC Aromatase Inhibitors, this includes Letrozole, Arimidex and Aromasin. The usage of these is very case dependant and I refuse to touch this subject without knowing the person's situation very in depth.
Other OTC Estrogen Modulating Agents:
Indole-3 Carbinole - Quite possibly the only working estrogen channeling agent, this prevents the formation of 16-hydroxylated estrogen by forming a weaker and easier to modulate 2-hydroxylated estrogen.
Chrysin, Di-indoylmethane (DIM) and phytoestrogenic plants that people claim to help with estrogen control should be avoided IMHO.
Putting the above products into practice:
The Taper -
'The Taper' can be defined as the gradual increase/decrease in the amount of product ingested over a period of time.
With a 100% OTC post cycle therapy, you will taper down with your selected AI. To not blanket statement this and be too general, it's usually case dependant with your particular product, I will give several examples later on though, not to worry!
With a NON-OTC post cycle therapy, you will usually taper your SERM downwards and inversely taper your AI upwards. An additional 2 week down-taper of your AI is a good idea to employ here.
Raising Testosterone:
Please keep in mind that anti-estrogens raise testosterone as well, but this is a dedicated pathway that I'm about to discuss.
Zinc/Magnesium - This is, in my humble opinion, the most effective way to boost testosterone naturally. Dosing your favorite ZMA product if fine, for those who buy these seperately, Dosing your Zinc at 30mgs nightly and your Magnesium at 400mgs nightly is fine, I prefer to dose the above amounts twice daily, not including my normal mineral intake.
There are herbs and extracts that claim to raise testosterone. We are almost all familiar with Tribulus and a few of the others. Let's discuss these individually shall we?
Tribulus Terrestis - Trib is so controversial anymore due to new science and technology, despite the arguements that it doesn't actually raise testosterone, it may still do so by an alternate pathway (via the Luteinizing hormone increases it provides) Either way you look at it, it WILL have a nice effect on libido and is something I always incorporate.
Avena Sativa - This oat is well known for increasing libido and sex drive.
Eurycoma Longifolia - Aka Long Jack and Tongkat Ali, this particular evergreen tree is great for libido and other sexual characteristics, and a few studies showing it may cause apoptosis in breast cells.
There are several other herbs and formulas sprouting up all over the place, I touched on what I personally felt are the worthwhile ones, but I did NOT touch on even a high percentage of them all.
Cortisol Modulation:
Cortisol receives a lot of bad press and is quite often frowned upon with an almost genocidical approach taken to it when people are informed of it's true nature. Be at ease everybody, cortisol aint all that bad, he's kewl, just not all the time, HA!
There's a variety of options availabe today to help reduce cortisol, I wanna touch base on 4 of them.
- 7-hydroxy-dehydroepiandrosterone (AKA 7-OH)
- 17 beta-Androstenetriol (AKA 17ß-Triol™)
- Dehydroepiandrosterone (AKA DHEA)
- Phellodenron and Magnolia Extract (AKA Relora™)
Once again, there's plenty of other options, but these are what I wanna touch base on. LOL
- 7-OH is a sulfate of DHEA and is nodded at in approval in it's effect on cortisol modulation
- 17ß-Triol™ is once again, another DHEA metabolite that is gaining more and more approval in the industry.
- DHEA just HAD to be included considering it's effects on... well everything. I don't recommend using this during the PCT timeframe, but when not in PCT, it may be a viable option for helping with cortisol.
- Relora™ was included because this is something I tend to lean torwards as a staple anymore, it's calming and relaxation promoting effects are great, this is definitely something that I intend to put some time into researching heavily.
We've got the basics covered kids! Let's continue on with the additions of Supporting Supplements, Gynecomastia, Mock up scenarios, and an FAQ section.