IGF Study

[Right Hook]

Not sure I completely understand this...but figured I'd post for others who might.

Journal of Clinical Endocrinology & Metabolism, doi:10.1210/jc.2007-0887
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
92/12/4820 most recent

The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 12 4820-4826
Copyright © 2007 by The Endocrine Society
Implications for Prostate Cancer of Insulin-Like Growth Factor-I (IGF-I) Genetic Variation and Circulating IGF-I Levels
Mattias Johansson, James D. McKay, Fredrik Wiklund, Sabina Rinaldi, Martijn Verheus, Carla H. van Gils, Göran Hallmans, Katarina Bälter, Hans-Olov Adami, Henrik Grönberg, Pär Stattin and Rudolf Kaaks

Departments of Surgical and Perioperative Sciences (M.J., P.S.), Urology and Andrology, and Public Health and Clinical Medicine (G.H.), Umeå University Hospital, 901 85 Umeå, Sweden; International Agency for Research on Cancer (J.D.M., S.R.), 69372 Lyon, France; Department of Medical Epidemiology and Biostatistics (F.W., K.B., H.-O.A., H.G.), Karolinska Institutet, 17177 Stockholm, Sweden; Julius Center for Health Sciences and Primary Care (M.V., C.H.v.G.), University Medical Center Utrecht, 85500 Utrecht, The Netherlands; Department of Epidemiology (H.-O.A.), Harvard University, Boston, Massachusetts 02215; and Division of Cancer Epidemiology (R.K.), German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany

Address all correspondence and requests for reprints to: Mattias Johansson, Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, 901 85 Umeå, Sweden. E-mail: Mattias.Johansson@oc.umu.se.

Background: Elevated levels of circulating IGF-I have consistently been associated with increased prostate cancer risk. We recently found a haplotype in the 3' region of the IGF-I gene associated with increased risk of prostate cancer, and we hypothesized that the observed association is mediated by circulating IGF-I.

Materials and Methods: We analyzed haplotypes and three haplotype-tagging single nucleotide polymorphisms (htSNPs) in the 3' region of the IGF-I gene in relation to circulating levels IGF-I in 698 control subjects from the CAncer Prostate in Sweden (CAPS) study and 575 cases and controls from the prospective Northern Sweden Health and Disease Cohort (NSHDC) study. We also performed a meta-analysis of these two and four other association studies on genetic variation in the 3' region of the IGF-I gene in relation to circulating IGF-I levels.

Results: The IGF-I haplotype previously associated with prostate cancer risk, labeled "TCC," was associated with elevated levels of IGF-I in the CAPS study (P = 0.02), but not in the NSHDC study. In contrast, two of the three IGF-I htSNPs tagging this haplotype, rs6220 and rs7136446, were associated with elevated levels of IGF-I in the NSHDC (P = 0.03 and P = 0.04, respectively), but not in the CAPS study. In the meta-analysis, the TCC haplotype and the rs6220 SNP were associated with elevated levels of circulating IGF-I (P = 0.001 and P < 0.0001, respectively).

Conclusions: Genetic variation in the 3' region of the IGF-I gene seems to influence circulating levels of IGF-I. This observation is consistent with the hypothesis that variation in the IGF-I gene plays a role in prostate cancer susceptibility by influencing circulating levels of IGF-I.

[transXisomer]

Basically it just says genetics play a role in IGF-1 production, some hypothesize variations in this gene may make some people more susceptible to certain cancers.

[jomi822]

ive read contradicting reports that say HGH and other igf regulating substances may prevent cancer by accelerating the cell cycle.

what the fuck ever, give me HGH

[Iron Warrior]

It shouldn't be that harmful when used with caution and moderation. It might also be related to one's IGF-I gene.

[Dr. Packenwood]

Originally Posted by jomi822

ive read contradicting reports that say HGH and other igf regulating substances may prevent cancer by accelerating the cell cycle.

what the fuck ever, give me HGH

H-G-H!

POWERBAARRRRRRRZ!

[Gixxer82]

Originally Posted by jomi822

ive read contradicting reports that say HGH and other igf regulating substances may prevent cancer by accelerating the cell cycle.

what the fuck ever, give me HGH

yeah! what he said!

[dinoiii]

Originally Posted by Travis

Not sure I completely understand this...but figured I'd post for others who might.

Originally Posted by transXisomer

Basically it just says genetics play a role in IGF-1 production, some hypothesize variations in this gene may make some people more susceptible to certain cancers.

Well, understand that a "haplotype" is most often referred to as a particular location on a chromosome that codes for a gene together.

There are different ends to the gene that dictate its translation (how it is read and as a result what it produces to the outside world). This happens to be at the 3' end (or downstream) on the gene where the variations are seen that dictate IGF-1 expression.

For more information about IGF-1 and its relation to prostate cancer...please continue to keep up to date with my subforum (I spoke of it in there, and I will try and find it with more time).

Basically, the linkage between estradiol and SHBG to prostate cancer (why nettle extracts are prostate protective) is related here.

Recall that SHBG sits atop prostate cells and estrogen comes and attaches which directs the IGF-1 to stimulate growth of the cells (i.e. - uncontrolled growth = cancer).


Hopefully, I haven't lost anyone.


D_

[sfearl1]

Originally Posted by dinoiii

Well, understand that a "haplotype" is most often referred to as a particular location on a chromosome that codes for a gene together.

There are different ends to the gene that dictate its translation (how it is read and as a result what it produces to the outside world). This happens to be at the 3' end (or downstream) on the gene where the variations are seen that dictate IGF-1 expression.

For more information about IGF-1 and its relation to prostate cancer...please continue to keep up to date with my subforum (I spoke of it in there, and I will try and find it with more time).

Basically, the linkage between estradiol and SHBG to prostate cancer (why nettle extracts are prostate protective) is related here.

Recall that SHBG sits atop prostate cells and estrogen comes and attaches which directs the IGF-1 to stimulate growth of the cells (i.e. - uncontrolled growth = cancer).


Hopefully, I haven't lost anyone.


D_

so would supplementing nettle root extracts be a good precautionary step while dosing igf?

[jomi822]

id be more worried about your heart than your prostate while using igf.

nettle root is an indirect way of fixing the problem, saw palmetto is what you really want to use. early research into SARMS included looking at the actions of the phytochemicals in saw palmetto extracts.

[Right Hook]

Originally Posted by dinoiii

Basically, the linkage between estradiol and SHBG to prostate cancer (why nettle extracts are prostate protective) is related here.

Recall that SHBG sits atop prostate cells and estrogen comes and attaches which directs the IGF-1 to stimulate growth of the cells (i.e. - uncontrolled growth = cancer).

D_

Would it be wrong to assume (yes I am making an "ass" of myself again ) to then say that when using an exogenous source of IGF you wouldnt want to simultaneously be using heavy AI's at the same time, correct? It could theoretically increase the potential for uncontrolled growth/cancer?