CJC-1295 Info

[Right Hook]

Bored, and sorta researching this peptide. Figured I'd post any relevant info I found in this thread:

This study shows the long half life of CJC-1295. Interesting as dosing would not have to be as often or even post workout like IGF-1. Also I would assume this like other GH releasing peptides would improve recovery in PCT as increased IGF levels also increase LH receptors.

Can anyone assist in dosing based on this study? It appears they dosed 30-60mcg's/kg. So for a 200lb man would this be roughly 2727mcg's or 2.7mg's/day? I'd assume this was the entire amount used over the course of the 28-49 days?

Prolonged Stimulation of Growth Hormone and IGF-1 Secretion by CJC-1295, a Long-acting Analogue of Growth Hormone-Releasing Hormone, in Healthy Adults
Sam L. Teichman, Ann Neale, Betty Lawrence, Catherine Gagnon, Jean-Paul Castaigne, and Lawrence A. Frohman*

WinPharm Associates, San Ramon CA.; ConjuChem, Inc., Montréal, Québéc, Canada; Section of Endocrinology, Department of Medicine, University of Illinois at Chicago, Chicago IL

* To whom correspondence should be addressed. E-mail: Frohman@uic.edu.

Context: Therapeutic use of growth hormone-releasing hormone (GHRH) to enhance GH secretion is limited by its short duration of action.

Objective: To examine the pharmacokinetic profile, pharmacodynamic effects, and safety of CJC-1295, a long-acting GHRH analog.

Design: Two randomized, placebo-controlled, double-blind, ascending dose trials with durations of 28 and 49 days.

Setting: Two investigational sites.

Participants: Healthy subjects, ages 21 to 61 yr.

Interventions: sc administration of CJC-1295 or placebo in one of 4 ascending single doses in the first study and in 2 - 3 weekly or biweekly doses in the second study.

Main Outcome Measures: Peak concentrations and area under the curve (AUC) of GH and IGF-1; standard pharmacokinetic parameters for CJC-1295.

Results: After a single injection of CJC-1295, there were dose-dependent increases in mean plasma GH concentrations by 2-10 fold for ≥ 6 days and in mean plasma IGF-1 concentrations by 1.5- to 3-fold for 9 - 11 days. The estimated half-life of CJC-1295 was 5.8 - 8.1 days. After multiple CJC-1295 doses, mean IGF-1 levels remained above baseline for up to 28 days. No serious adverse reactions were reported.

Conclusions: sc administration of CJC-1295 resulted in sustained, dose-dependent increases in GH and IGF-1 levels in healthy adults and was safe and relatively well-tolerated, particularly at doses of 30 µg/kg or 60 µg/kg. There was evidence of a cumulative effect after multiple doses. These data support the potential utility of CJC-1295 as a therapeutic agent.

[Right Hook]

Lots of info here:

http://lib.bioinfo.pl/auth:Frohman,LA

About midway down on that page...

[TripDog]

fuckin newbs make me sick.........

[Right Hook]

Originally Posted by TripDog

fuckin newbs make me sick.........

LOL, I linked you to share your experience with it...not noob up this thread.


P.S. Gangsta rap made me do it

[MentalTwitch]

mmmmhhmmmm so i started you on peptide info huh....huh....yea i know....
haha.
This is my next one to start lookin into.

[Right Hook]

Originally Posted by MentalTwitch

mmmmhhmmmm so i started you on peptide info huh....huh....yea i know....
haha.
This is my next one to start lookin into.

Ahh yes, lol. I use IGF in PCT but I'm looking at possible alternatives. Stuff is hella expensive so I have to talk myself into it being worth it ya know.