Clen & Beta Receptors

[meksi]

I came across some interesting info elsewhere and wanted to get your thoughts and hopefully generate discussion.

Most Clen researchers (in general) seem to subscribe to the thought that Clen should be cycled 2wks on with 2wks off. In the off weeks, some will use ECA to allow beta receptors to upregulate. I have come across (unvalidated) information that states ECA will continue to hit those same receptors. If this is true what is the school of the thought to the traditional cycle of Clen followed up ECA? Does ECA not downregulate as intensely as Clen, therefore receptors get a break?

Along the same lines, Benadryl seems to be used at about 50mg-100mg to assist in the upregulation of beta2 receptors. Would you agree with this mindset? Would the two weeks of ECA allow for receptor recovery? Could you provide an example of how to best administer Benadryl? I came across information about Ketotifen and am aware it does the same as Benadryl but do not know what dangers lay beneath its use as a research chemical.

[mad dog]

Interesting post hope someone knowledgable in this area chimes in.

[ENIGMA]

The time clenbuterol can be ran really comes down to each individual and how there body tolerates it. I personally have had good success running 3 weeks clen, 3 weeks EC, 2 weeks clen, 2 weeks EC. Benadryl can be ran in conjunction with clen if you are wanting to run it for a longer period of time (4-5 weeks is the longest i would run it even with the benadryl). Another option is to run a clen/keto combo. Most research companies offer this and it has the same effects as running clen and benadryl in that you are able to run it for longer periods of time.

[mad dog]

That actually clears up a lot of confusion[how would albuterol fit into this
scheme].

[ENIGMA]

one of the key benefits to albuterol is it can be ran for longer time periods than clen. I personally think clen does a much better job than albuterol whenit comes to weight loss though.

[mad dog]

you r right but the sides on clen r sometimes too much.

[ENIGMA]

The same sides can be had with albuterol. Really the only sides that are hard to avoid are the shakes and raised body temp. Cramps can be avoided by taking a potassium supplement. The degree of side effects will depend solely on the person and how they react to the chemical.

[meksi]

Understood...

If ECA hits the beta receptors just as Clen does, what is the train of thought behind those that run ECA in their off weeks? Whats the benefit if the receptors are not getting a break?

Is anybody aware of any work/studies that show effects (positive/negative) of running Clen for longer periods? (i.e. 6wks+) If running Benadryl/Keto, how much longer can the body stay in the "game" before it calls it quits? (studies/literature?)

If running Benadryl/Keto to upregulate B2 receptors, does this affect the purported anticatabolic effects of Clen?

[meksi]

bumpity bump...anybody? bueller? doc?

[Hank Vangut]

taken from another source.....

Since we´re speaking about beta-receptors and upregulation, here, let me address the claim that you can use ephedrine (or the ECA stack), alternating with clen, in order to avoid receptor downgrade. I´m not sure where this rumor came from, but it is totally incorrect.

To dispel this myth, lets examine ephedrine for a second. Remember when I said that using clenbuterol to stimulate the beta-2 receptors is like hitting a tack with a hammer? Well, Ephedrine is like a sledge-hammer, it hits the beta-2´s and everything around them. That´s because it´s not selective, but rather it stimulates other receptors to a great degree as well.

Anyway, one of those receptors that ephedrine hits is the Beta-2 (yeah...the same one as Clen). As you can see from the graph below (ephedrine is represented by the the solid circles), it reduced Beta-2-AndrenergicReceptor (what we call, in laymens terms, the "Beta-2 receptor") levels to 32% of the control level after 24 hours. Read this again:

Ephedrine, in this study, reduces Beta-2 receptor levels to 32% of control after 24 hours.