How SERM's Work

[Sampson]

Could someone please explain to me how exactly a SERM works, and what it is doing in your body compared to using something like ATD? How exactly are the two better, and what makes one a better option over the other...if one is a "BETTER" option at all?

[thesinner]

Ok, I'm going to explain how ephedrine works, to better illustrate how SERMs and AI's work:

Very simply ephedrine blocks up specific andregenic receptors, thus freeing up more of your body's adrenaline to perform its other functions in the body.


A SERM works in a similar manner. It blocks certain estrogenic receptors to free up estrogen to perform other functions in the body.


An AI works in pretty much the opposite manner of a SERM. AI's take up the aromatase enzyme, which frees up more testosterone to perform other functions in the body.

[Voodoo]

Originally Posted by thesinner

Ok, I'm going to explain how ephedrine works, to better illustrate how SERMs and AI's work:

Very simply ephedrine blocks up specific andregenic receptors, thus freeing up more of your body's adrenaline to perform its other functions in the body.


A SERM works in a similar manner. It blocks certain estrogenic receptors to free up estrogen to perform other functions in the body.


An AI works in pretty much the opposite manner of a SERM. AI's take up the aromatase enzyme, which frees up more testosterone to perform other functions in the body.

you must spread rep around before pimping sinner again...

[RisingAgainst]

Originally Posted by Voodoo

you must spread rep around before pimping sinner again...

What he meant to say is: "Dude, I can't hug your nuts any tighter than I already am!" LOL

[Voodoo]

i was starting to wonder how your post count got so high and then i realized....

[Mass_69]

Originally Posted by thesinner

Ok, I'm going to explain how ephedrine works, to better illustrate how SERMs and AI's work:

Very simply ephedrine blocks up specific andregenic receptors, thus freeing up more of your body's adrenaline to perform its other functions in the body.


A SERM works in a similar manner. It blocks certain estrogenic receptors to free up estrogen to perform other functions in the body.


An AI works in pretty much the opposite manner of a SERM. AI's take up the aromatase enzyme, which frees up more testosterone to perform other functions in the body.

Actually, ephedrine is a b-adreneric agonist, not antagonist, meaning it opens these receptors to accepting adrenal hormones like adrenaline.

The HPTA stimulating effect of most SERMs in men comes from blocking estrogen receptors at the hypothalamus or pituitary. Estrogens in men come from aromatization of androgens. If the receptors are tricked into thinking the body is low on estrogens, it upregulates the production of androgens in hopes of creating more estrogens downstream.

It's actually a very similar concept with AIs, as you are tricking the body into upregulating testosterone production because of lack of estrogens. One difference is, the AIs will actually lower the serum estrogens vs. just blocking their effects... of course the debate goes on and on about estrogen-receptor upregulation from this, but the limited data I have seen suggests this is not a problem with steriodal AIs.

[thesinner]

Originally Posted by Mass_69

Actually, ephedrine is a b-adreneric agonist, not antagonist, meaning it opens these receptors to accepting adrenal hormones like adrenaline.

The HPTA stimulating effect of most SERMs in men comes from blocking estrogen receptors at the hypothalamus or pituitary. Estrogens in men come from aromatization of androgens. If the receptors are tricked into thinking the body is low on estrogens, it upregulates the production of androgens in hopes of creating more estrogens downstream.

It's actually a very similar concept with AIs, as you are tricking the body into upregulating testosterone production because of lack of estrogens. One difference is, the AIs will actually lower the serum estrogens vs. just blocking their effects... of course the debate goes on and on about estrogen-receptor upregulation from this, but the limited data I have seen suggests this is not a problem with steriodal AIs.

I could've sworn ephedrine was an antogonist, but I'm not in the mood to argue. It's so easy to mix up the two words (antogonist vs. agonist), perhaps you're right.

[Mass_69]

Originally Posted by thesinner

I could've sworn ephedrine was an antogonist, but I'm not in the mood to argue. It's so easy to mix up the two words (antogonist vs. agonist), perhaps you're right.

Naw, no one's arguing. It's is a beta-agonist: http://www.ncbi.nlm.nih.gov/sites/en...ubmed_RVDocSum

I think you meant "antagonist" instead of "antogonist." That might be part of the confusion.

[dinoiii]

Mass Man is correct men!


D_

[muad33b]

Originally Posted by dinoiii

Mass Man is correct men!


D_

I was reading his post thinking, hmm, sounds good, but I gotta see what D_ has to say... Nice one Mass!

I think we need a "Dinoiii Approved Post/Thread" GIF now!