Fat guys use Letro

[Right Hook]

Thought this was interesting if nothing else:

1: Eur J Endocrinol. 2008 May;158(5):741-7.Click here to read Links
Letrozole once a week normalizes serum testosterone in obesity-related male hypogonadism.
Loves S, Ruinemans-Koerts J, de Boer H.

Department of Internal Medicine, Ziekenhuis Rijnstate, Wagnerlaan 55, 6800 TA Arnhem, The Netherlands.

OBJECTIVE: Isolated hypogonadotropic hypogonadism (IHH) is frequently observed in severely obese men, probably as a result of increased estradiol (E(2)) production and E(2)-mediated negative feedback on pituitary LH secretion. Aromatase inhibitors can reverse this process. This study evaluates whether letrozole once a week can normalize serum testosterone in severely obese men and maintain its long term effect. DESIGN: Open, uncontrolled 6-month pilot study in 12 severely obese men (body mass index>35.0 kg/m(2)) with obesity-related IHH and free testosterone levels <225 pmol/l, treated with 2.5 mg letrozole once a week for 6 months. RESULTS: Six weeks of treatment reduced total E(2) from 123+/-11 to 58+/-7 pmol/l (P<0.001, mean+/-s.e.m.), and increased serum LH from 4.4+/-0.6 to 11.1+/-1.5 U/l (P<0.001). Total testosterone rose from 5.9+/-0.5 to 19.6+/-1.4 nmol/l (P<0.001), and free testosterone from 163+/-13 to 604+/-50 pmol/l (P<0.001). Total testosterone rose to within the normal range in all subjects, whereas free testosterone rose to supraphysiological levels in 7 out of 12 men. The testosterone and E(2) levels were stable throughout the week and during the 6-month treatment period. CONCLUSION: Letrozole 2.5 mg once a week produced a sustained normalization of serum total testosterone in obese men with IHH. However, free testosterone frequently rose to supraphysiological levels. Therefore, a starting dose <2.5 mg once a week is recommended.

PMID: 18426834

[sfearl1]

bumpsky

[TripDog]

Originally Posted by sfearl1

bumpsky

bumpyourmutha

[swolloniron]

I think you might be overlooking a few things.

1) Most BB's or Strength trained athletes should be pretty damn close, if not obese by BMI, so the definition is always a little suspect.
(here is a BMI calc if you don't believe me: Calculate your BMI - Standard BMI Calculator)

2) How many people who cycle (esp "bulk") are really less than 10% BF? Probably only about 5% or less that claim to be.

3) How many people overeat on cycle (esp wet compounds) and gain 20-50% fat mass with their muscle?

4) Even if it was pretty clean, cortisol rebound causes a decent amount of adipose deposit.

Now where is all this going? Primarily in relation to Adipose driven aromatization (hence the study on OBESE men).

Probably 90% of the people who go on a bulk cycle and up with a higher BF% at the end of their cycle....(+post cycle cort) hence their adipose is a critical factor regarding aromatization.

Not saying everyone is a fat ass, but I am saying that reaching supraphysiological test levels with once a week dosing over 6 weeks could be very useful to anyone with a double digit body fat in post cycle (which is honestly the majority - no one likes to admit their 12%, 15% or 20% BF.....10% or 9% just "looks" better....but its all about statistics. Look around your gym and at the guys you know cycle. Whats their body fat in PCT? Unless it was a hard cut with some clen, probably > 9%).

[Right Hook]

Originally Posted by swolloniron

I think you might be overlooking a few things.

Ummm, I posted nothing but the abstract.

1) Most BB's or Strength trained athletes should be pretty damn close, if not obese by BMI, so the definition is always a little suspect.
(here is a BMI calc if you don't believe me: Calculate your BMI - Standard BMI Calculator)

Agree and disagree. Most BB's or Strength trained athletes would not meet both categories of severely obese (BMI >35.0 kg/m2) with obesity-related IHH.

2) How many people who cycle (esp "bulk") are really less than 10% BF? Probably only about 5% or less that claim to be.

I'd agree.

3) How many people overeat on cycle (esp wet compounds) and gain 20-50% fat mass with their muscle?

Most newbs.

4) Even if it was pretty clean, cortisol rebound causes a decent amount of adipose deposit

When? PCT I'd assume your referring to?

Now where is all this going? Primarily in relation to Adipose driven aromatization (hence the study on OBESE men).

Probably 90% of the people who go on a bulk cycle and up with a higher BF% at the end of their cycle....(+post cycle cort) hence their adipose is a critical factor regarding aromatization.

Not saying everyone is a fat ass, but I am saying that reaching supraphysiological test levels with once a week dosing over 6 weeks could be very useful to anyone with a double digit body fat in post cycle (which is honestly the majority - no one likes to admit their 12%, 15% or 20% BF.....10% or 9% just "looks" better....but its all about statistics. Look around your gym and at the guys you know cycle. Whats their body fat in PCT? Unless it was a hard cut with some clen, probably > 9%).

I'd agree. But that just leads us back to the age old "AI in PCT debate". Other things to think about are libido, joint issues, etc.