CoQ10 Supplementation on Performance (Study)

[Right Hook]

This was from March 4th but just read it. Didnt exactly use weightlifters in the study, but the dosage of CoQ10 they used would be relatively affordable for a possible increase in performance:

Effects of acute and 14-day coenzyme Q10 supplementation on exercise performance in both trained and untrained individuals

Matthew Cooke email, Mike Iosia email, Thomas Buford email, Brian Shelmadine email, Geoffrey Hudson email, Chad Kerksick email, Christopher Rasmussen email, Mike Greenwood email, Brian Leutholtz email, Darryn Willoughby email and Richard Kreider email

Journal of the International Society of Sports Nutrition 2008, 5:8doi:10.1186/1550-2783-5-8
Published: 4 March 2008
Abstract (provisional)

Background

To determine whether acute (single dose) and/or chronic (14-days) supplementation of CoQ10 will improve anaerobic and/or aerobic exercise performance by increasing plasma and muscle CoQ10 concentrations within trained and untrained individuals.
Methods

Twenty-two aerobically trained and nineteen untrained male and female subjects (26.1+/-7.6 yrs, 172+/-8.7 cm, 73.5+/-17 kg, and 21.2+/-7.0%) were randomized to ingest in a double-blind manner either 100 mg of a dextrose placebo (CON) or a fast-melt CoQ10 supplement (CoQ10) twice a day for 14-days. On the first day of supplementation, subjects donated fasting blood samples and a muscle biopsy. Subjects were then given 200 mg of the placebo or the CoQ10 supplement. Sixty minutes following supplement ingestion, subjects completed an isokinetic knee extension endurance test, a 30-second wingate anaerobic capacity test, and a maximal cardiopulmonary graded exercise test interspersed with 30-minutes of recovery. Additional blood samples were taken immediately following each exercise test and a second muscle biopsy sample was taken following the final exercise test. Subjects consumed twice daily (morning and night), 100mg of either supplement for a period of 14-days, and then returned to the lab to complete the same battery of tests. Data was analyzed using repeated measures ANOVA with an alpha of 0.05.
Results

Plasma CoQ10 levels were significantly increased following 2 weeks of CoQ10 supplementation (p<0.001); while a trend for higher muscle CoQ10 levels was observed after acute CoQ10 ingestion (p=0.098). A trend for lower serum superoxide dismutase (SOD) was observed following acute supplementation with CoQ10 (p=0.06), whereas serum malondialdehyde (MDA) tended to be significantly higher (p<0.05). Following acute ingestion of CoQ10, plasma CoQ10 levels were significantly correlated to muscle CoQ10 levels; maximal oxygen consumption; and treadmill time to exhaustion. A trend for increased time to exhaustion was observed following 2 weeks of CoQ10 supplementation (p=0.06).
Conclusions

Acute supplementation with CoQ10 resulted in higher muscle CoQ10 concentration, lower serum SOD oxidative stress, and higher MDA levels during and following exercise. Chronic CoQ10 supplementation increased plasma CoQ10 concentrations and tended to increase time to exhaustion. Results indicate that acute and chronic supplementation of CoQ10 may affect acute and/or chronic responses to various types of exercise.

The study above indicated a trend for lower serum superoxide dismutase (SOD) after supplementation. My understanding of that is basically lower SOD levels mean the muscle/cell is better utilizing oxygen....or do I have that backwards?

Also it indicates malondialdehyde (MDA) levels were significantly higher after supplementation....this is bad, correct?



More info from the mayo clinic can be found here:

Coenzyme Q10 - MayoClinic.com

Particular areas of use that interested me (although these were given "C" ratings) were:

Exercise Performance
Increasing sperm count (idiopathic spermatozoa)
Kidney failure <----maybe to prevent issues from trenbolone related kidney stress
High blood pressure (hypertension)

[growstrong]

good post Travis! Very interesting. This is used to lower BP too right? or am I way off?

[LLLLern]

thanks for the read

[xjsynx]

Nice +reps

[xjsynx]

+rep IOU

[Right Hook]

Originally Posted by growstrong

good post Travis! Very interesting. This is used to lower BP too right? or am I way off?

Yep good for BP too....then there is that whole Idebenone debate on which is better.


No worries xjsyx! Your all good!

[growstrong]

Originally Posted by Travis

Yep good for BP too....then there is that whole Idebenone debate on which is better.


No worries xjsyx! Your all good!

knew i picked that up somewhere but didnt know if it was dated info... Thanks travis

[mad dog]

Good post TRAVIS co-q10 has a multitude of benefits.

[growstrong]

Originally Posted by mad dog

Good post TRAVIS co-q10 has a multitude of benefits.

So I hear... pops has BP issues so I got him to start taking this so i will report back if any possitive results!