Enteric coated creatine

[GeneGnome]

A recent product came out with this claiming a large amount of creatine is destroyed in the stomach and enteric coating will allow for the utilization of more creatine and thus the dose requirement decreases.

However, creatine monohydrate absorption is nearly 100%

Deldicque L, D?combaz J, Zbinden Foncea H, Vuichoud J, Poortmans JR, Francaux M. Kinetics of creatine ingested as a food ingredient. Eur J Appl Physiol. 2008;102:133?143. doi: 10.1007/s00421-007-0558-9.

They claim the conversion to creatinine in the stomach is significant. From the same article:

Once ingested, creatine has potentially various fates.
Due to the low pH in the stomach, it could be transformed
in creatinine. However, the rate of conversion is rather
slow (Cannan and Shore 1928). The half-lives of degradation
are 55, 7.5 and 40.5 days at pH values 1.4, 3.7 and
6.8, respectively (Chanutin, 1926). Thus, considering a pH
of stomach near to 2 and a dose of 2 g, only 1% of this
amount would be converted to creatinine within the first
hour after ingestion. This rate of creatine degradation is in
the same range in the intestinal tract (pH = 6-7). As creatine
remains a longer period of time in the intestine than in
the stomach, it is likely to be degraded in a larger proportion
at this level. However, the stable plasma creatinine
concentration following ingestion of creatine, in addition to
its undetectable amount in feces, corroborate the hypothesis
that the conversion of creatine to creatinine remains
negligible in the gastrointestinal tract.

Creatine monohydrate is effective, safe, inexpensive, and extensively studied.

This product use only 2g total of creatine, which of monohydrate itself may not be sufficient for some people, but they also attach other molecules which would increase the dose requirement because of molecular weight. Thus this will not be enough creatine to significantly increase muscle creatine.

And, we don't know if the enteric coating will break down in the appropriate place.

Do not be fooled!

[Right Hook]

Originally Posted by GeneGnome

However, creatine monohydrate absorption is nearly 100%

Deldicque L, D?combaz J, Zbinden Foncea H, Vuichoud J, Poortmans JR, Francaux M. Kinetics of creatine ingested as a food ingredient. Eur J Appl Physiol. 2008;102:133?143. doi: 10.1007/s00421-007-0558-9.

They claim the conversion to creatinine in the stomach is significant. From the same article:

I've heard this before and never understood it (regarding creatine mono being destroyed in the stomach or water).

Good post mod man.

[Right Hook]

Btw since they are a board sponsor I would expect some sort of response...

[GeneGnome]

Originally Posted by Travis

Btw since they are a board sponsor I would expect some sort of response...

I look forward to it.

[B-natural]

Wow, lets not be too obvious here

[GQ-Nemesis]

nice post ..ive read through it ..part of it ..i was lost at ..but i got the gist of the article

[B-natural]

So, all well and good, you found the word creatine, jumped to monohyrdate, then bashed the product.

YOU mentioned creatine monohyrdate, where we even speciy we haven't included CEE or KA, and make NO mention of CM as we understand its 99% absorption rate. There is no mention of the specific creatine that loses absorption, just that some forms can degrade rapidly within the first two hours after ingestion.

As for the enteric coating, several studies support its use to allow better stability when passing through the GI tract to aid in absorption and limit degradation.

[RisingAgainst]

Originally Posted by B-natural

So, all well and good, you found the word creatine, jumped to monohyrdate, then bashed the product.

YOU mentioned creatine monohyrdate, where we even speciy we haven't included CEE or KA, and make NO mention of CM as we understand its 99% absorption rate. There is no mention of the specific creatine that loses absorption, just that some forms can degrade rapidly within the first two hours after ingestion.

As for the enteric coating, several studies support its use to allow better stability when passing through the GI tract to aid in absorption and limit degradation.

OHHHHHHHHHHHHH!!

[Gixxer82]

Originally Posted by B-natural

So, all well and good, you found the word creatine, jumped to monohyrdate, then bashed the product.

YOU mentioned creatine monohyrdate, where we even speciy we haven't included CEE or KA, and make NO mention of CM as we understand its 99% absorption rate. There is no mention of the specific creatine that loses absorption, just that some forms can degrade rapidly within the first two hours after ingestion.

As for the enteric coating, several studies support its use to allow better stability when passing through the GI tract to aid in absorption and limit degradation.

I think he was saying, why use creatine with an enteric coating when monohydrate already has a good absorption rating.