IBE X-Lean (Possible Reduce XT/Lean Xtreme Alternative)

[lionelxxl]

Have you guys checked out IBE's new cortisol reducing product?

http://www.nutraplanet.com/product/1420/x-lean.html

What do you think of its ingredients? Similar to Reduce XT and Lean Xtreme? I noticed they used the beta isomer of DHEA exclusively unlike the previous 2 which contained a blend of alpha/beta isomers.

I tried questioning the decision of their choice on another board but it was conveniently skimmed over by them.

So.. is the beta isomer the important, active one or...?

[GeneGnome]

Keep asking

Ask them about the statements in this thread: http://www.mindandmuscle.net/forum/i...howtopic=22896

[transXisomer]

^^^ jealous hater

[dinoiii]

Originally Posted by lionelxxl

Have you guys checked out IBE's new cortisol reducing product?

http://www.nutraplanet.com/product/1420/x-lean.html

What do you think of its ingredients? Similar to Reduce XT and Lean Xtreme? I noticed they used the beta isomer of DHEA exclusively unlike the previous 2 which contained a blend of alpha/beta isomers.

I tried questioning the decision of their choice on another board but it was conveniently skimmed over by them.

So.. is the beta isomer the important, active one or...?

Doesn't look dosed high enough on either ingredient if we're only talking 50mg of the combined effort considering oral bioavailability anyway - REGARDLESS OF ISOMER CONCENTRATION.


D_

[GeneGnome]

I'm a little confused- Robboe states in the MM thread that the beta is useless for cortisol yet Dr. D was with DS at the time.

Also, there is a patent on the beta isomer, the lowest dose listed is incidentally 50mg, so maybe this is their way of getting around it. Though I haven't a clue if it would matter anyway since they have another ingredient.

[lionelxxl]

What exactly is Androstenetriol, the other ingredient in the blend?

[mad dog]

Can we revisit this thread with the IBE reps chiming in, this is a interesting thread.

[mad dog]

BUMP AND BUMP.

[DAdams91982]

Originally Posted by lionelxxl

What exactly is Androstenetriol, the other ingredient in the blend?

Sorry fellas, didn't see this. I am at work so cant really take the time to post up everything, so here is a study on Androstentriol. And a website saying the Beta isomer had anti cort effects, and not listing the alpha. Take it for what it is worth... I dont have my resources here at work... so I will point the man to this thread.

Steroid Acne - A new outlook at the causes and remedies of acne.

Androstentriol information:

Antiglucocorticoid function of androstenetriol.

Loria RM.

Virginia Commonwealth University, Medical College of Virginia, Richmond 23298-0678, USA. Loria@gems.vcu.edu

The anti-inflammatory and immunosuppressive functions of corticosteroids have been well established and characterized. In contrast, a different group of native steroids, which include dehydroepiandrosterone (DHEA) and two of its metabolites, androstenediol (5-androstene-3 beta-17 beta-diol, AED) and androstenetriol (5-androstene-3 beta-7 beta-17 beta-triol, beta AET), function in vivo to up-regulate host immune response against infections and counteract stress-induced immunosuppression. Indeed, DHEA and particularly, AED and beta AET, have been shown to protect mice from viral, bacterial, and parasitic infections. In vivo, these three hormones are in opposition to the widely demonstrated immunosuppressive action of glucocorticoids, suggesting a possible new immune regulation mechanism. The individual activity in vitro of each of these steroids, i.e. DHEA, AED, and beta AET, on a mitogen-induced mixed splenocyte proliferation assay were determined. The results showed that DHEA suppressed the proliferation of cultures activated with concanavalin A (ConA) or lipopolysaccharide (LPS) in a dose-dependent manner. AED had little influence on the activation response. However, beta AET potentiated the response to both mitogens significantly above control. The regulation of the cytokine secretion, of both interleukin-2 (IL-2) and interleukin-3 (IL-3), from ConA-activated lymphocytes was affected in the same manner. These functions were depressed by DHEA, unaffected by AED, and potently increased by beta AET. Moreover, the classic immunosuppressive effects of hydrocortisone on ConA-induced lymphocyte proliferation, as well as on IL-2 and IL-3 production, were unaffected by being co-cultured with DHEA and only minimally counteracted by AED at high doses. In contrast, co-culturing with beta AET significantly counteracted the immunosuppressive effects of hydrocortisone on lymphocyte proliferation and cytokine production. These data show that in-vivo, DHEA, AED, and beta AET may have some similar functions, while in vitro, their effects are dramatically different from one another. Only beta AET could markedly potentiate the cellular response by increasing lymphocyte activation and counteracting the immnosuppressive activity of hydrocortisone on lymphocyte proliferation and cytokine production.

[mad dog]

D what is the ideal dosage for this compound to work effectively?